174606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1599401..1599930 Replicon chromosome
Accession NZ_CP062362
Organism Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF721_RS07935 Protein ID WP_001103933.1
Coordinates 1599401..1599718 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF721_RS07940 Protein ID WP_001058488.1
Coordinates 1599721..1599930 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF721_RS07910 (1594516) 1594516..1594857 - 342 WP_001190614.1 hypothetical protein -
IF721_RS07915 (1595393) 1595393..1596034 - 642 WP_064140196.1 pathogenicity island protein -
IF721_RS07920 (1596031) 1596031..1596411 - 381 WP_000356927.1 hypothetical protein -
IF721_RS07925 (1596742) 1596742..1598451 - 1710 WP_000447454.1 DUF927 domain-containing protein -
IF721_RS07930 (1598465) 1598465..1599334 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF721_RS07935 (1599401) 1599401..1599718 - 318 WP_001103933.1 DUF1474 family protein Toxin
IF721_RS07940 (1599721) 1599721..1599930 - 210 WP_001058488.1 hypothetical protein Antitoxin
IF721_RS07945 (1599923) 1599923..1600069 - 147 WP_000780975.1 hypothetical protein -
IF721_RS07950 (1600116) 1600116..1600376 - 261 WP_001147662.1 hypothetical protein -
IF721_RS07955 (1600378) 1600378..1600575 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF721_RS07960 (1600665) 1600665..1601342 + 678 WP_239858572.1 helix-turn-helix transcriptional regulator -
IF721_RS07965 (1601438) 1601438..1602574 + 1137 WP_000592973.1 site-specific integrase -
IF721_RS07970 (1602668) 1602668..1604209 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1582828..1607006 24178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T174606 WP_001103933.1 NZ_CP062362:c1599718-1599401 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T174606 NZ_CP081202:6908262-6908561 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT174606 WP_001058488.1 NZ_CP062362:c1599930-1599721 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174606 NZ_CP081202:6908558-6908848 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References