Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2097615..2098129 Replicon chromosome
Accession NZ_CP062360
Organism Staphylococcus aureus strain NAS_AN_157

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF722_RS10390 Protein ID WP_000581792.1
Coordinates 2097615..2097824 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF722_RS10395 Protein ID WP_000138934.1
Coordinates 2097836..2098129 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF722_RS10370 (2093123) 2093123..2094481 - 1359 WP_072491791.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF722_RS10375 (2094496) 2094496..2095566 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF722_RS10380 (2095884) 2095884..2097086 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF722_RS10385 (2097350) 2097350..2097487 - 138 WP_000828354.1 Lmo0850 family protein -
IF722_RS10390 (2097615) 2097615..2097824 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF722_RS10395 (2097836) 2097836..2098129 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF722_RS10400 (2098295) 2098295..2099779 + 1485 WP_098818134.1 cardiolipin synthase -
IF722_RS10405 (2099807) 2099807..2100454 + 648 WP_065315756.1 HD domain-containing protein -
IF722_RS10410 (2101191) 2101191..2102063 - 873 WP_072491794.1 membrane protein insertase YidC -
IF722_RS10415 (2102149) 2102149..2102790 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174594 WP_000581792.1 NZ_CP062360:c2097824-2097615 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174594 NZ_CP081201:c1911618-1911334 [Pseudomonas phytophila]
ATGTCCACTACCCTAGTGCCGTTTGATATGGCAGCGATCCTTGACAGCGACGAGGCGATCAACGAATACCTCTCCCAGGT
TCTTGCTGATGGTGATACGGACGAACTGATTCGTGCCGTGGGCCATGTAGCAAAAGCACGTGGCATGGCTCAGATAGCCA
AGGATTCAGGACTTGGCAGAGCCAGTCTGTACAAAGCTTTGGCTCCAGGTGCAAAGCCGCGCTTTGACACAGTACTGAAA
GTATTAACTGCACTCGGAATCAAGCTGGTCACTCATCGTCCTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT174594 WP_000138934.1 NZ_CP062360:c2098129-2097836 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174594 NZ_CP081201:c1911915-1911622 [Pseudomonas phytophila]
GTGACGTACACAATACAGCAGACACAAATATTCACCCATTGGCACGCAGGCTTGCGCGACATACGGGCCAGGATCGCTAT
AGCGCGACGTATTGAGCGCGTATCGGCAGGTAATCTGGGAGACGTGAAAGCCGTCGGCGAAGGAGTGTCCGAGATGCGCG
TAGATGTCGGCGCAGGATACAGAATCTATTTCACCACCCGGGACCGTACGATCATCGTGCTCCTGGTCGGCGGGGATAAA
TCAACTCAGCCGGGTGATATAAGGCAGGCAAAAATAATGGCGAAGGAGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References