Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1869898..1870674 Replicon chromosome
Accession NZ_CP062360
Organism Staphylococcus aureus strain NAS_AN_157

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag IF722_RS09025 Protein ID WP_098817916.1
Coordinates 1869898..1870050 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag IF722_RS09030 Protein ID WP_001251217.1
Coordinates 1870075..1870674 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF722_RS09010 (1865987) 1865987..1866808 + 822 WP_240025144.1 RluA family pseudouridine synthase -
IF722_RS09015 (1867258) 1867258..1868643 - 1386 WP_072491880.1 class II fumarate hydratase -
IF722_RS09020 (1868839) 1868839..1869234 - 396 WP_000901023.1 hypothetical protein -
IF722_RS09025 (1869898) 1869898..1870050 - 153 WP_098817916.1 SAS053 family protein Toxin
IF722_RS09030 (1870075) 1870075..1870674 - 600 WP_001251217.1 hypothetical protein Antitoxin
IF722_RS09035 (1870833) 1870833..1871303 - 471 WP_098817917.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF722_RS09040 (1871308) 1871308..1872435 - 1128 WP_172440429.1 tRNA epoxyqueuosine(34) reductase QueG -
IF722_RS09045 (1872586) 1872586..1873308 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF722_RS09050 (1873301) 1873301..1874758 - 1458 WP_000649900.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5864.22 Da        Isoelectric Point: 3.9367

>T174588 WP_098817916.1 NZ_CP062360:c1870050-1869898 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMGQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174588 NZ_CP081200:c1512163-1511876 [Pseudomonas sp. 3-2]
ATGCACGTTGATTGGCTGAAGACTGCATTAAGAAATCTCGATGACGAAGCGGCTTACATCGCGAGAGAGAACCCCAAGGC
AGCCGCCGAATTTGTTCACGACATGCTTGCCACTGTCGATCAACTCGCACAATTTCCAGCCGTGGGGCGTGAGGGCCGCT
TGCCCGGAACCCGGGAATGGGTTGTGCCAGACCGTCCTTACCTGATCCCTTACCGCGTTCGCCACGGCCGTTTACAAGTG
TTGCGGATTTTCCATACCCGTCGCCTGCCGCCCACTGCCTGGATATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22391.52 Da        Isoelectric Point: 5.1445

>AT174588 WP_001251217.1 NZ_CP062360:c1870674-1870075 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIEFIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174588 NZ_CP081200:c1512392-1512153 [Pseudomonas sp. 3-2]
ATGTCAGTCATGTCTCTACGTCTTCCAGATGAACTGGCGGACACCCTCGCCACGCTCGCCAAAGCCACCGGACGCAGCAA
GTCTTACCTGGCGGTCGATGCCCTTCGCGAGTACATCGCGCGCGAAGCCTGGCAGATCGAAGAAATACAGAAAGCGCTGA
ACGAAGCCGATGCAGGGGATTTCGCTTCCGCCGAAGACGTCAGGGAAATCGCAAACAAATGGAGCGCCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References