Detailed information of TA system TA174585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 852689..853166
• Replicon: chromosome
• Accession: NZ_CP062360
• Organism: Staphylococcus aureus strain NAS_AN_157

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF722_RS04125
• Protein ID: WP_000052076.1
• Coordinates: 852689..852877 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: IF722_RS04130
• Protein ID: WP_072491425.1
• Coordinates: 852906..853166 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF722_RS04095 (848728)	848728..849198	+	471	WP_072491423.1	hypothetical protein	-
IF722_RS04100 (849539)	849539..850225	+	687	WP_072491424.1	thermonuclease family protein	-
IF722_RS04105 (850582)	850582..850782	+	201	WP_001059082.1	cold-shock protein	-
IF722_RS04110 (851280)	851280..851498	-	219	WP_000005880.1	hypothetical protein	-
IF722_RS04115 (851560)	851560..851844	-	285	WP_001004404.1	hypothetical protein	-
IF722_RS04120 (851932)	851932..852501	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
IF722_RS04125 (852689)	852689..852877	-	189	WP_000052076.1	hypothetical protein	Toxin
IF722_RS04130 (852906)	852906..853166	-	261	WP_072491425.1	hypothetical protein	Antitoxin
IF722_RS04135 (853506)	853506..853709	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF722_RS04140 (853706)	853706..853942	-	237	WP_072491426.1	hypothetical protein	-
IF722_RS04145 (854167)	854167..854748	+	582	WP_001140696.1	histidine phosphatase family protein	-
IF722_RS04150 (854821)	854821..855438	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
IF722_RS04155 (855594)	855594..856088	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
IF722_RS04160 (856487)	856487..856909	-	423	WP_000974457.1	organic hydroperoxide resistance protein	-
IF722_RS04165 (857057)	857057..857773	+	717	WP_072491427.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174585 WP_000052076.1 NZ_CP062360:c852877-852689 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174585 NZ_CP081200:328924-329106 [Pseudomonas sp. 3-2]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAGGCCCAAGGCGTTGAGTTCCAAACCGGCAAGGGCAGTCATTTCAAGGT
TTCCTTGAATGGCAAATCAACTGTCTTTCCCGACCACGGAGCCAAGGAGATGGGCGAAGGGTTGAGAAAATCGATAATCA
AACAGCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9879.99 Da
• Isoelectric Point: 4.0624

>AT174585 WP_072491425.1 NZ_CP062360:c853166-852906 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSSTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174585 NZ_CP081200:329138-329563 [Pseudomonas sp. 3-2]
ATGTTCGAATATGCGTTGGAAGTCCACGAGGAGCCGGGCAGTGTCTGGTTGTCCTGCGCAGAAATTCCAGAGATGCACGC
CGCTGGCGACACCCTCGAGGAAGCACTCGACGGCGCTATAGATGCGATGGAAACGGCCTTGTCGATTTACGTCGATGATC
GCCGGTTGATTCCGACAGGTGATGCGGGAGAGCAGGAAAGTGACGCGGTATTGCGTCTGCCTGCACTGACTGCCGCAAAG
GTCGGGTTGTGGAATGCCCTTCTCGAGTCTGGGGTGAGCAAGGCTGAACTGGCACGGCGCTTGGGTGTGCAACGACCCCA
GGTAGATCGGTTAGTCGATTTCCTGCATCACTCCAAGATTGAGAATGTTGAGCGTGCGTTGCAGCAGCTTGGACGGCGGA
TTTTACTTTCGGTTGAGGCTGCGTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18