Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2261843..2262366 Replicon chromosome
Accession NZ_CP062358
Organism Staphylococcus aureus strain NAS_AN_184

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF726_RS11025 Protein ID WP_000074049.1
Coordinates 2262100..2262366 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF726_RS11020 Protein ID WP_000587616.1
Coordinates 2261843..2262100 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF726_RS11005 (2258340) 2258340..2259089 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
IF726_RS11010 (2259284) 2259284..2260861 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF726_RS11015 (2261029) 2261029..2261484 - 456 WP_000732076.1 DUF1307 domain-containing protein -
IF726_RS11020 (2261843) 2261843..2262100 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF726_RS11025 (2262100) 2262100..2262366 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF726_RS11030 (2262721) 2262721..2263797 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF726_RS11035 (2264045) 2264045..2264707 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF726_RS11040 (2264700) 2264700..2265476 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IF726_RS11045 (2265872) 2265872..2267059 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T174574 WP_000074049.1 NZ_CP062358:2262100-2262366 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174574 NZ_CP081192:c4547368-4547195 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174574 WP_000587616.1 NZ_CP062358:2261843-2262100 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174574 NZ_CP081192:c4547692-4547396 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References