Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2626297..2626811 Replicon chromosome
Accession NZ_CP062356
Organism Staphylococcus aureus strain NAS_AN_203

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF727_RS12920 Protein ID WP_000581792.1
Coordinates 2626602..2626811 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF727_RS12915 Protein ID WP_000138932.1
Coordinates 2626297..2626590 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF727_RS12895 (2621460) 2621460..2622101 + 642 WP_000483153.1 thiamine phosphate synthase -
IF727_RS12900 (2622187) 2622187..2623059 + 873 WP_000725802.1 membrane protein insertase YidC -
IF727_RS12905 (2623972) 2623972..2624619 - 648 WP_001187630.1 HD domain-containing protein -
IF727_RS12910 (2624647) 2624647..2626131 - 1485 WP_000571549.1 cardiolipin synthase -
IF727_RS12915 (2626297) 2626297..2626590 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF727_RS12920 (2626602) 2626602..2626811 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF727_RS12925 (2626939) 2626939..2627076 + 138 WP_000828354.1 Lmo0850 family protein -
IF727_RS12930 (2627340) 2627340..2628542 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF727_RS12935 (2628860) 2628860..2629930 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF727_RS12940 (2629945) 2629945..2631303 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174564 WP_000581792.1 NZ_CP062356:2626602-2626811 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174564 NZ_CP081192:1888469-1888720 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174564 WP_000138932.1 NZ_CP062356:2626297-2626590 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174564 NZ_CP081192:1888717-1888971 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References