Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2639565..2640079 Replicon chromosome
Accession NZ_CP062354
Organism Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF730_RS13025 Protein ID WP_000581792.1
Coordinates 2639870..2640079 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF730_RS13020 Protein ID WP_000138932.1
Coordinates 2639565..2639858 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF730_RS13000 (2634929) 2634929..2635570 + 642 WP_000483156.1 thiamine phosphate synthase -
IF730_RS13005 (2635656) 2635656..2636528 + 873 WP_000725800.1 membrane protein insertase YidC -
IF730_RS13010 (2637240) 2637240..2637887 - 648 WP_001187630.1 HD domain-containing protein -
IF730_RS13015 (2637915) 2637915..2639399 - 1485 WP_000571549.1 cardiolipin synthase -
IF730_RS13020 (2639565) 2639565..2639858 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF730_RS13025 (2639870) 2639870..2640079 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF730_RS13030 (2640207) 2640207..2640344 + 138 WP_000828354.1 Lmo0850 family protein -
IF730_RS13035 (2640608) 2640608..2641810 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF730_RS13040 (2642128) 2642128..2643198 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF730_RS13045 (2643213) 2643213..2644571 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174547 WP_000581792.1 NZ_CP062354:2639870-2640079 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174547 NZ_CP081189:2405006-2405290 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174547 WP_000138932.1 NZ_CP062354:2639565-2639858 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174547 NZ_CP081189:2404768-2405016 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References