Detailed information of TA system TA174538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1173453..1173930
• Replicon: chromosome
• Accession: NZ_CP062354
• Organism: Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF730_RS05885
• Protein ID: WP_000052076.1
• Coordinates: 1173742..1173930 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF730_RS05880
• Protein ID: WP_001059690.1
• Coordinates: 1173453..1173713 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF730_RS05845 (1168846)	1168846..1169562	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF730_RS05850 (1169710)	1169710..1170132	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF730_RS05855 (1170531)	1170531..1171025	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF730_RS05860 (1171180)	1171180..1171797	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF730_RS05865 (1171870)	1171870..1172451	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF730_RS05870 (1172676)	1172676..1172912	+	237	WP_000368687.1	hypothetical protein	-
IF730_RS05875 (1172909)	1172909..1173112	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF730_RS05880 (1173453)	1173453..1173713	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF730_RS05885 (1173742)	1173742..1173930	+	189	WP_000052076.1	hypothetical protein	Toxin
IF730_RS05890 (1174118)	1174118..1174687	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF730_RS05895 (1174775)	1174775..1175059	+	285	WP_001004394.1	hypothetical protein	-
IF730_RS05900 (1175121)	1175121..1175346	+	226	Protein_1138	hypothetical protein	-
IF730_RS05905 (1175841)	1175841..1176041	-	201	WP_001059082.1	cold-shock protein	-
IF730_RS05910 (1176398)	1176398..1177084	-	687	WP_001566557.1	thermonuclease family protein	-
IF730_RS05915 (1177425)	1177425..1177895	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / clpP	1145981..1204870	58889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174538 WP_000052076.1 NZ_CP062354:1173742-1173930 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174538 NZ_CP081187:c4775811-4775500 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174538 WP_001059690.1 NZ_CP062354:1173453-1173713 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174538 NZ_CP081187:c4775499-4775209 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56