Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2252634..2253157 Replicon chromosome
Accession NZ_CP062352
Organism Staphylococcus aureus strain NAS_AN_233

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF733_RS10980 Protein ID WP_000074049.1
Coordinates 2252891..2253157 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF733_RS10975 Protein ID WP_000587616.1
Coordinates 2252634..2252891 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF733_RS10960 (2249132) 2249132..2249881 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
IF733_RS10965 (2250076) 2250076..2251653 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF733_RS10970 (2251821) 2251821..2252276 - 456 WP_000732076.1 DUF1307 domain-containing protein -
IF733_RS10975 (2252634) 2252634..2252891 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF733_RS10980 (2252891) 2252891..2253157 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF733_RS10985 (2253512) 2253512..2254588 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF733_RS10990 (2254836) 2254836..2255498 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF733_RS10995 (2255491) 2255491..2256267 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IF733_RS11000 (2256663) 2256663..2257850 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T174520 WP_000074049.1 NZ_CP062352:2252891-2253157 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174520 NZ_CP081178:4259776-4260069 [Pseudomonas mandelii]
ATGAATTATATTGTTCAACAAACTATGATCTTCGTGGCATGGCATGCCTCAGTTCGTGACTTGCGGGCGAAGATTGCTAT
CGCTCGTCGCATTGATCGTGCCTCTGCAGGTAACCTGGGTGATATCAAGCCGGTGGGAGACGGCGTTTCCGAAATGCGCG
TGGACGTCGGCGGCGGCTATCGGGTCTACTTCACTTTGCGAAACAGTGTCGTCATTGTGCTTTTGGCCGGTGGTGATAAA
TCTTCGCAAACCGCCGATATCAGGCGGGCTAAAAAATTGGCAAAGGAGGTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174520 WP_000587616.1 NZ_CP062352:2252634-2252891 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174520 NZ_CP081178:4260072-4260380 [Pseudomonas mandelii]
ATGAGCCAGACTTTGACTACTTTCGATATGGCGGCACTGCTGGACAGTGACGAAGCCATTAGCGAGTACCTCTCACAAGT
GCTCGCAGAGGGCGATAACGAGGAATTTCTTCGTGCTATCGGATACGTGGTGAAAGCGCGCGGAATGACACAGATTGCCA
AGGACTCGGGTATGGGTCGCGAAAGCCTGTACAAGGCCTTCGCGCCCGGTGCAAAACCACGCTTTGATACGGTTTTGAAG
GTCATCCATGCCCTCGGCATCGATCTCTGTGCGCAGCCAGGTCATTCGATCAATCACTCGGTGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References