174519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1156006..1156483 Replicon chromosome
Accession NZ_CP062352
Organism Staphylococcus aureus strain NAS_AN_233

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF733_RS05745 Protein ID WP_000052076.1
Coordinates 1156295..1156483 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF733_RS05740 Protein ID WP_001059690.1
Coordinates 1156006..1156266 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF733_RS05705 (1151399) 1151399..1152115 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
IF733_RS05710 (1152263) 1152263..1152685 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF733_RS05715 (1153084) 1153084..1153578 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF733_RS05720 (1153733) 1153733..1154350 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IF733_RS05725 (1154423) 1154423..1155004 - 582 WP_001140693.1 histidine phosphatase family protein -
IF733_RS05730 (1155229) 1155229..1155465 + 237 WP_000349581.1 hypothetical protein -
IF733_RS05735 (1155462) 1155462..1155665 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF733_RS05740 (1156006) 1156006..1156266 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF733_RS05745 (1156295) 1156295..1156483 + 189 WP_000052076.1 hypothetical protein Toxin
IF733_RS05750 (1156671) 1156671..1157240 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF733_RS05755 (1157328) 1157328..1157612 + 285 WP_001004399.1 hypothetical protein -
IF733_RS05760 (1157674) 1157674..1157892 + 219 WP_000005886.1 hypothetical protein -
IF733_RS05765 (1158384) 1158384..1158584 - 201 WP_001059082.1 cold-shock protein -
IF733_RS05770 (1158941) 1158941..1159627 - 687 WP_000141557.1 thermonuclease family protein -
IF733_RS05775 (1159968) 1159968..1160489 - 522 WP_049311898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174519 WP_000052076.1 NZ_CP062352:1156295-1156483 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174519 NZ_CP081178:c2532145-2531795 [Pseudomonas mandelii]
ATGGATGCTCTTTTCATCGAATTACGTATGTTCCAGAAACATCGAGACGAGTACCTGGATGACGATCTGTTTCGCAGCTT
TCAACTGGAGTTGCTGAAGAATCCAGAAGCGGGCGATCTCATTGAGGGCACCGGTGGGCTGCGCAAAATCCGCTTCTGCG
ATCAACGACGAGGCAAGGGCAAGCGCGGCGGATTGCGGGTGATTTATTACTGGTGGTCAGGCTTCGATCAATTCTGGCTG
TTCACCGTGTACAGCAAAAACGAGCAAGACGACCTGTCGCCCTCCCAGAAAAACATTTTCAGACAAGCGCTAGATAGAGA
AATCAACACGAGATCCCACTATGAAACGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174519 WP_001059690.1 NZ_CP062352:1156006-1156266 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174519 NZ_CP081178:c2531805-2531491 [Pseudomonas mandelii]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGCCTCGAAGCGCTGGCCGAAGAGCGCCAAGGCAAGATCACTCTGCG
CACCCACAAGGTCCAGCTGCCAAAACTGATGCCCATCACGGCTGAGGAAGTGGTTGCCATACGCCAACAGCTCAACCTCT
CCCGGCCAGTGTTCGCCATGTATCTGCGCACCAACACCCGAACCCTTGAGAACTGGGAACAGGGACGGGCAATACCCAAT
GCCCAAGCCACGACCCTGATACGTCTGGTTGAACGCTTTCCGCAGACGATCGAACAGCTCGCAGCCCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References