Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsdAT/- |
| Location | 2634575..2635089 | Replicon | chromosome |
| Accession | NZ_CP062350 | ||
| Organism | Staphylococcus aureus strain NAS_AN_250 | ||
Toxin (Protein)
| Gene name | TsdT | Uniprot ID | A0A641A3V2 |
| Locus tag | IF736_RS13105 | Protein ID | WP_000581793.1 |
| Coordinates | 2634880..2635089 (+) | Length | 70 a.a. |
Antitoxin (Protein)
| Gene name | TsdA | Uniprot ID | W8UW13 |
| Locus tag | IF736_RS13100 | Protein ID | WP_000138932.1 |
| Coordinates | 2634575..2634868 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF736_RS13080 (2630037) | 2630037..2630678 | + | 642 | WP_000483155.1 | thiamine phosphate synthase | - |
| IF736_RS13085 (2630764) | 2630764..2631636 | + | 873 | WP_240018947.1 | membrane protein insertase YidC | - |
| IF736_RS13090 (2632250) | 2632250..2632897 | - | 648 | WP_031590210.1 | HD domain-containing protein | - |
| IF736_RS13095 (2632925) | 2632925..2634409 | - | 1485 | WP_000571549.1 | cardiolipin synthase | - |
| IF736_RS13100 (2634575) | 2634575..2634868 | + | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
| IF736_RS13105 (2634880) | 2634880..2635089 | + | 210 | WP_000581793.1 | heavy metal-associated domain-containing protein | Toxin |
| IF736_RS13110 (2635217) | 2635217..2635354 | + | 138 | WP_000828354.1 | Lmo0850 family protein | - |
| IF736_RS13115 (2635617) | 2635617..2636819 | - | 1203 | WP_240018948.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
| IF736_RS13120 (2637137) | 2637137..2638207 | + | 1071 | WP_000159627.1 | D-alanine--D-alanine ligase | - |
| IF736_RS13125 (2638222) | 2638222..2639580 | + | 1359 | WP_106905739.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7809.75 Da Isoelectric Point: 4.1008
>T174511 WP_000581793.1 NZ_CP062350:2634880-2635089 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
Download Length: 210 bp
>T174511 NZ_CP081109:c2824255-2823680 [Sulfitobacter mediterraneus]
ATGAGTGACTATGCCGACCGTTTCACGGCGCTGATCGACGCAAATGTTCTGGCGTGTGCGATGCGCAGAAACATAATCTT
GTCACTGGCCGAGGCTGGACTTTTTCGGCCTCGGTGGAGCGACAGGATTATGGACGAGACTGCCGGTGCGATCGCCAAGA
TTACGAAGGGCGGCGCTGACACCATCAAGCAGCGTTCTGCTATGGAACGCGCCTTTCCCGAGGCATGCGTCACTGGGTAT
GCTGGACTTGAAGCAGGGCTGGAGTTGCCTGACCCGGATGACCGCCATGTTCTTGCTGCGGCGATTACAACATCCGCGCA
GGTGATTGTGACGGAAAACCTTAAGGATTTCCCAAGCGAAGCGCTCGCCCCTTTTGACATCGATGCAATCTCCGCCGATG
AGTTCATTTCTGATGCGATTGAACTTGACCCACTCGCAGCTGTCGCGGCCCTGCGTAAAATGCGTGAGCGGTTCAAAAAT
CCCGACATGGATGCCGAAGCATTGTTGCAGCGGATCAAGGCTCGAAAATTATTTCAAACTGCCGAGACGCTGCATCAGTT
TATGGAGTTGCTATAG
ATGAGTGACTATGCCGACCGTTTCACGGCGCTGATCGACGCAAATGTTCTGGCGTGTGCGATGCGCAGAAACATAATCTT
GTCACTGGCCGAGGCTGGACTTTTTCGGCCTCGGTGGAGCGACAGGATTATGGACGAGACTGCCGGTGCGATCGCCAAGA
TTACGAAGGGCGGCGCTGACACCATCAAGCAGCGTTCTGCTATGGAACGCGCCTTTCCCGAGGCATGCGTCACTGGGTAT
GCTGGACTTGAAGCAGGGCTGGAGTTGCCTGACCCGGATGACCGCCATGTTCTTGCTGCGGCGATTACAACATCCGCGCA
GGTGATTGTGACGGAAAACCTTAAGGATTTCCCAAGCGAAGCGCTCGCCCCTTTTGACATCGATGCAATCTCCGCCGATG
AGTTCATTTCTGATGCGATTGAACTTGACCCACTCGCAGCTGTCGCGGCCCTGCGTAAAATGCGTGAGCGGTTCAAAAAT
CCCGACATGGATGCCGAAGCATTGTTGCAGCGGATCAAGGCTCGAAAATTATTTCAAACTGCCGAGACGCTGCATCAGTT
TATGGAGTTGCTATAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT174511 WP_000138932.1 NZ_CP062350:2634575-2634868 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT174511 NZ_CP081109:c2824716-2824252 [Sulfitobacter mediterraneus]
ATGATGATGCAAGCAAAAGAAGCGTTCGCAGAACGTCTGCCCGATCAGGTCGAAATTGAAAATGCTGACAGCCTTCGCCG
GATCCTTGCCTCGCAAGTGAACGGTGATGAGGCGGTTGAGCTGAGTCTAGCACTTGGCGAGAAGCAGATCGAACCCGTGA
CTTTGGCTCCAGCTCTGGCTGCATCCTTGATGGAGTTGTTGCGGCTGGTTTCAAGCGGCCGAGGGTTTCGGATGATCCCT
GTGGATGCAGAACTGACGACCCAACAAGCCGCTGATTTGTTGAATGTTTCGCGCCCACATCTCGTGAAGCTTTTAGAAGA
TGGGGATATTGCGTTCTATAAAACGGGGCGACACCGCCGTGTGAAAGCAGCGGATCTGTTTGAATACAAAAAGAAACGCG
ACACCGATCGCTCTGACGCACTGTCTGATCTCGCGGCAATGGACATGGAGAGCGATCTTTTATGA
ATGATGATGCAAGCAAAAGAAGCGTTCGCAGAACGTCTGCCCGATCAGGTCGAAATTGAAAATGCTGACAGCCTTCGCCG
GATCCTTGCCTCGCAAGTGAACGGTGATGAGGCGGTTGAGCTGAGTCTAGCACTTGGCGAGAAGCAGATCGAACCCGTGA
CTTTGGCTCCAGCTCTGGCTGCATCCTTGATGGAGTTGTTGCGGCTGGTTTCAAGCGGCCGAGGGTTTCGGATGATCCCT
GTGGATGCAGAACTGACGACCCAACAAGCCGCTGATTTGTTGAATGTTTCGCGCCCACATCTCGTGAAGCTTTTAGAAGA
TGGGGATATTGCGTTCTATAAAACGGGGCGACACCGCCGTGTGAAAGCAGCGGATCTGTTTGAATACAAAAAGAAACGCG
ACACCGATCGCTCTGACGCACTGTCTGATCTCGCGGCAATGGACATGGAGAGCGATCTTTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A641A3V2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | W8UW13 |