Detailed information of TA system TA174502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1168112..1168589
• Replicon: chromosome
• Accession: NZ_CP062350
• Organism: Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF736_RS05920
• Protein ID: WP_000052076.1
• Coordinates: 1168401..1168589 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF736_RS05915
• Protein ID: WP_001059690.1
• Coordinates: 1168112..1168372 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF736_RS05880 (1163504)	1163504..1164220	-	717	WP_000150016.1	type I 3-dehydroquinate dehydratase	-
IF736_RS05885 (1164368)	1164368..1164790	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF736_RS05890 (1165189)	1165189..1165683	+	495	WP_106905814.1	GNAT family N-acetyltransferase	-
IF736_RS05895 (1165839)	1165839..1166456	+	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
IF736_RS05900 (1166529)	1166529..1167110	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF736_RS05905 (1167335)	1167335..1167571	+	237	WP_000368687.1	hypothetical protein	-
IF736_RS05910 (1167568)	1167568..1167771	-	204	WP_240018987.1	sterile alpha motif-like domain-containing protein	-
IF736_RS05915 (1168112)	1168112..1168372	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF736_RS05920 (1168401)	1168401..1168589	+	189	WP_000052076.1	hypothetical protein	Toxin
IF736_RS05925 (1168777)	1168777..1169346	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF736_RS05930 (1169434)	1169434..1169718	+	285	WP_001004401.1	hypothetical protein	-
IF736_RS05935 (1169780)	1169780..1169998	+	219	WP_000005887.1	hypothetical protein	-
IF736_RS05940 (1170494)	1170494..1170694	-	201	WP_001059082.1	cold-shock protein	-
IF736_RS05945 (1171051)	1171051..1171737	-	687	WP_001641381.1	thermonuclease family protein	-
IF736_RS05950 (1172078)	1172078..1172554	-	477	WP_000824477.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174502 WP_000052076.1 NZ_CP062350:1168401-1168589 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174502 NZ_CP081016:c4150743-4150447 [Pseudomonas sp. 2hn]
ATGGAGAAAAGAACGCCGCACTGTACGTTGGAGCGAATAAAAGCGCTGCTCGCAGCCGAGCGAGTAAGGGTAACCTCTAC
CGCGCTTCGAGGAGCCAGGGCTCTGGGGCTGGATTACCCAGGTATGCTTGAGGTGATCAGCAGGCTGGAGCGTGCTGATT
TCTACAAGAGCATGACCAGCTATGCCGATCACCTGGTCTGGCAGGACGTCTATCGACCGCTCACAGCAGTGGGGTATGTG
TATCTCAAACTGACGGTTGTCGATGATGTTCTTATCGTGTCCTTCAAGGAGCTGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174502 WP_001059690.1 NZ_CP062350:1168112-1168372 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174502 NZ_CP081016:c4150444-4150043 [Pseudomonas sp. 2hn]
ATGAGATGCCCGATTTGTGGTGGTGCCGAGCTTGCACCGGACACTCAGGACATGCCCTATCGCTACAAGGGCATGTCGAC
GCTTATTCCGCATGTCAGTGGTGATTATTGCCCTGCCTGTGGTGAGGCGGTGTTGAGTCATGCCGAAGCCATGCGTGTCA
GTGACCTGATGGTGGAGTTTGATCGGAAGATCAATGCTGAGGCTATTGACCCTGCCTTCATTGTTGCCGTGCGCAAGAAG
TTCGACCTCGACCAGCGTGAAGCGGGTGAAATCTTCGGGGGAGGCGTCAATGCGTTCTCTCGTTATGAAAATGGCAAGAC
CCGGCCGCCGGTCGCTTTGATCAAGCTGTTCAAGCTCCTGGATCGCCATCCGGAACTGTTCGAGGAAGTCAGGACTGCCT
GA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56