174487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1872688..1873202 Replicon chromosome
Accession NZ_CP062348
Organism Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag IF738_RS09520 Protein ID WP_000581793.1
Coordinates 1872688..1872897 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF738_RS09525 Protein ID WP_000138932.1
Coordinates 1872909..1873202 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF738_RS09500 (1868197) 1868197..1869555 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF738_RS09505 (1869570) 1869570..1870640 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
IF738_RS09510 (1870958) 1870958..1872160 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF738_RS09515 (1872423) 1872423..1872560 - 138 WP_000828354.1 Lmo0850 family protein -
IF738_RS09520 (1872688) 1872688..1872897 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
IF738_RS09525 (1872909) 1872909..1873202 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF738_RS09530 (1873368) 1873368..1874852 + 1485 WP_000571549.1 cardiolipin synthase -
IF738_RS09535 (1874880) 1874880..1875527 + 648 WP_001187628.1 HD domain-containing protein -
IF738_RS09540 (1876141) 1876141..1877013 - 873 WP_000725802.1 membrane protein insertase YidC -
IF738_RS09545 (1877099) 1877099..1877740 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T174487 WP_000581793.1 NZ_CP062348:c1872897-1872688 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T174487 NZ_CP081010:c4607649-4607476 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174487 WP_000138932.1 NZ_CP062348:c1873202-1872909 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174487 NZ_CP081010:c4607973-4607677 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References