174479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 526337..526814 Replicon chromosome
Accession NZ_CP062348
Organism Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF738_RS02605 Protein ID WP_000052076.1
Coordinates 526337..526525 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF738_RS02610 Protein ID WP_001059690.1
Coordinates 526554..526814 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF738_RS02575 (522327) 522327..522848 + 522 WP_000824464.1 hypothetical protein -
IF738_RS02580 (523189) 523189..523875 + 687 WP_001793574.1 thermonuclease family protein -
IF738_RS02585 (524232) 524232..524432 + 201 WP_001059082.1 cold-shock protein -
IF738_RS02590 (524928) 524928..525146 - 219 WP_000005886.1 hypothetical protein -
IF738_RS02595 (525208) 525208..525492 - 285 WP_001004401.1 hypothetical protein -
IF738_RS02600 (525580) 525580..526149 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF738_RS02605 (526337) 526337..526525 - 189 WP_000052076.1 hypothetical protein Toxin
IF738_RS02610 (526554) 526554..526814 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF738_RS02615 (527154) 527154..527357 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF738_RS02620 (527354) 527354..527590 - 237 WP_000368687.1 hypothetical protein -
IF738_RS02625 (527814) 527814..528395 + 582 WP_001140696.1 histidine phosphatase family protein -
IF738_RS02630 (528468) 528468..529085 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
IF738_RS02635 (529240) 529240..529734 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF738_RS02640 (530133) 530133..530555 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
IF738_RS02645 (530703) 530703..531419 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174479 WP_000052076.1 NZ_CP062348:c526525-526337 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174479 NZ_CP081010:2998134-2998412 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174479 WP_001059690.1 NZ_CP062348:c526814-526554 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174479 NZ_CP081010:2997941-2998132 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References