Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2781046..2781584 Replicon chromosome
Accession NZ_CP062346
Organism Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag IF739_RS13755 Protein ID WP_240017962.1
Coordinates 2781258..2781584 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag IF739_RS13750 Protein ID WP_001058489.1
Coordinates 2781046..2781255 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF739_RS13715 (2776292) 2776292..2776576 + 285 WP_031918283.1 co-chaperone GroES -
IF739_RS13720 (2776652) 2776652..2778268 + 1617 WP_000240648.1 chaperonin GroEL -
IF739_RS13725 (2778337) 2778337..2779509 - 1173 WP_240017958.1 tyrosine-type recombinase/integrase -
IF739_RS13730 (2779523) 2779523..2780197 - 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
IF739_RS13735 (2780370) 2780370..2780588 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
IF739_RS13740 (2780593) 2780593..2780910 + 318 WP_240017960.1 helix-turn-helix domain-containing protein -
IF739_RS13745 (2780907) 2780907..2781053 + 147 WP_000784885.1 hypothetical protein -
IF739_RS13750 (2781046) 2781046..2781255 + 210 WP_001058489.1 hypothetical protein Antitoxin
IF739_RS13755 (2781258) 2781258..2781584 + 327 WP_240017962.1 DUF1474 family protein Toxin
IF739_RS13760 (2781650) 2781650..2782519 + 870 WP_001002698.1 primase alpha helix C-terminal domain-containing protein -
IF739_RS13765 (2782533) 2782533..2784233 + 1701 WP_000447470.1 DUF927 domain-containing protein -
IF739_RS13770 (2784563) 2784563..2784943 + 381 WP_000356927.1 hypothetical protein -
IF739_RS13775 (2784940) 2784940..2785581 + 642 WP_001019762.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2773378..2823051 49673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12954.36 Da        Isoelectric Point: 4.3444

>T174478 WP_240017962.1 NZ_CP062346:2781258-2781584 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDNHGWHVDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Download         Length: 327 bp

>T174478 NZ_CP081010:2832788-2832895 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT174478 WP_001058489.1 NZ_CP062346:2781046-2781255 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174478 NZ_CP081010:c2832732-2832671 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References