Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1210071..1210548 | Replicon | chromosome |
| Accession | NZ_CP062346 | ||
| Organism | Staphylococcus aureus strain NAS_AN_261 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | IF739_RS06030 | Protein ID | WP_000052076.1 |
| Coordinates | 1210360..1210548 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF739_RS06025 | Protein ID | WP_001059690.1 |
| Coordinates | 1210071..1210331 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF739_RS05990 (1205462) | 1205462..1206178 | - | 717 | WP_031927536.1 | type I 3-dehydroquinate dehydratase | - |
| IF739_RS05995 (1206326) | 1206326..1206748 | + | 423 | WP_031927537.1 | organic hydroperoxide resistance protein | - |
| IF739_RS06000 (1207147) | 1207147..1207641 | + | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| IF739_RS06005 (1207798) | 1207798..1208415 | + | 618 | WP_047213256.1 | LysE/ArgO family amino acid transporter | - |
| IF739_RS06010 (1208488) | 1208488..1209069 | - | 582 | WP_001140691.1 | histidine phosphatase family protein | - |
| IF739_RS06015 (1209294) | 1209294..1209530 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| IF739_RS06020 (1209527) | 1209527..1209730 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF739_RS06025 (1210071) | 1210071..1210331 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF739_RS06030 (1210360) | 1210360..1210548 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| IF739_RS06035 (1210736) | 1210736..1211305 | + | 570 | WP_001106648.1 | lipoprotein N-acylation protein LnsA | - |
| IF739_RS06040 (1211393) | 1211393..1211677 | + | 285 | WP_001004397.1 | hypothetical protein | - |
| IF739_RS06045 (1211739) | 1211739..1211957 | + | 219 | WP_000005883.1 | hypothetical protein | - |
| IF739_RS06050 (1212454) | 1212454..1212654 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| IF739_RS06055 (1213011) | 1213011..1213697 | - | 687 | WP_000141556.1 | thermonuclease family protein | - |
| IF739_RS06060 (1214038) | 1214038..1214520 | - | 483 | WP_000824492.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T174466 WP_000052076.1 NZ_CP062346:1210360-1210548 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T174466 NZ_CP081010:c47349-46924 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCTCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCTCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT174466 WP_001059690.1 NZ_CP062346:1210071-1210331 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT174466 NZ_CP081010:c47715-47380 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |