Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 123343..124119 Replicon chromosome
Accession NZ_CP062346
Organism Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)


Gene name tsbT Uniprot ID A0A380DXA2
Locus tag IF739_RS00775 Protein ID WP_000031110.1
Coordinates 123967..124119 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag IF739_RS00770 Protein ID WP_001251219.1
Coordinates 123343..123942 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF739_RS00750 (119259) 119259..120716 + 1458 WP_031927464.1 ABC transporter permease subunit -
IF739_RS00755 (120709) 120709..121431 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF739_RS00760 (121582) 121582..122709 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF739_RS00765 (122714) 122714..123184 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF739_RS00770 (123343) 123343..123942 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
IF739_RS00775 (123967) 123967..124119 + 153 WP_000031110.1 SAS053 family protein Toxin
IF739_RS00780 (124779) 124779..125174 + 396 WP_000901023.1 hypothetical protein -
IF739_RS00785 (125370) 125370..126755 + 1386 WP_000116225.1 class II fumarate hydratase -
IF739_RS00790 (127206) 127206..128027 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5964.34 Da        Isoelectric Point: 3.9953

>T174465 WP_000031110.1 NZ_CP062346:123967-124119 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174465 NZ_CP081009:c4532535-4532428 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT174465 WP_001251219.1 NZ_CP062346:123343-123942 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174465 NZ_CP081009:4532582-4532648 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380DXA2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References