Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tsbAT/- |
| Location | 123343..124119 | Replicon | chromosome |
| Accession | NZ_CP062346 | ||
| Organism | Staphylococcus aureus strain NAS_AN_261 | ||
Toxin (Protein)
| Gene name | tsbT | Uniprot ID | A0A380DXA2 |
| Locus tag | IF739_RS00775 | Protein ID | WP_000031110.1 |
| Coordinates | 123967..124119 (+) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | tsbA | Uniprot ID | A0A0D1IYN8 |
| Locus tag | IF739_RS00770 | Protein ID | WP_001251219.1 |
| Coordinates | 123343..123942 (+) | Length | 200 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF739_RS00750 (119259) | 119259..120716 | + | 1458 | WP_031927464.1 | ABC transporter permease subunit | - |
| IF739_RS00755 (120709) | 120709..121431 | + | 723 | WP_000590809.1 | amino acid ABC transporter ATP-binding protein | - |
| IF739_RS00760 (121582) | 121582..122709 | + | 1128 | WP_000379980.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| IF739_RS00765 (122714) | 122714..123184 | + | 471 | WP_000181394.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| IF739_RS00770 (123343) | 123343..123942 | + | 600 | WP_001251219.1 | glucosamine-6-phosphate isomerase | Antitoxin |
| IF739_RS00775 (123967) | 123967..124119 | + | 153 | WP_000031110.1 | SAS053 family protein | Toxin |
| IF739_RS00780 (124779) | 124779..125174 | + | 396 | WP_000901023.1 | hypothetical protein | - |
| IF739_RS00785 (125370) | 125370..126755 | + | 1386 | WP_000116225.1 | class II fumarate hydratase | - |
| IF739_RS00790 (127206) | 127206..128027 | - | 822 | WP_000669377.1 | RluA family pseudouridine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5964.34 Da Isoelectric Point: 3.9953
>T174465 WP_000031110.1 NZ_CP062346:123967-124119 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ
Download Length: 153 bp
>T174465 NZ_CP081009:c4532535-4532428 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22357.50 Da Isoelectric Point: 5.1445
>AT174465 WP_001251219.1 NZ_CP062346:123343-123942 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
>AT174465 NZ_CP081009:4532582-4532648 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A380DXA2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D1IYN8 |