Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2684666..2685180 Replicon chromosome
Accession NZ_CP062342
Organism Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF741_RS13320 Protein ID WP_000581792.1
Coordinates 2684971..2685180 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF741_RS13315 Protein ID WP_000138932.1
Coordinates 2684666..2684959 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF741_RS13295 (2680030) 2680030..2680671 + 642 WP_000483156.1 thiamine phosphate synthase -
IF741_RS13300 (2680757) 2680757..2681629 + 873 WP_000725800.1 membrane protein insertase YidC -
IF741_RS13305 (2682341) 2682341..2682988 - 648 WP_001187630.1 HD domain-containing protein -
IF741_RS13310 (2683016) 2683016..2684500 - 1485 WP_000571549.1 cardiolipin synthase -
IF741_RS13315 (2684666) 2684666..2684959 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF741_RS13320 (2684971) 2684971..2685180 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF741_RS13325 (2685308) 2685308..2685445 + 138 WP_000828354.1 Lmo0850 family protein -
IF741_RS13330 (2685709) 2685709..2686911 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF741_RS13335 (2687229) 2687229..2688299 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF741_RS13340 (2688314) 2688314..2689672 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174439 WP_000581792.1 NZ_CP062342:2684971-2685180 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174439 NZ_CP081008:c4654461-4654354 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174439 WP_000138932.1 NZ_CP062342:2684666-2684959 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174439 NZ_CP081008:4654508-4654574 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References