Detailed information of TA system TA174413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1199801..1200278
• Replicon: chromosome
• Accession: NZ_CP062340
• Organism: Staphylococcus aureus strain NAS_AN_275

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF742_RS06090
• Protein ID: WP_000052076.1
• Coordinates: 1200090..1200278 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF742_RS06085
• Protein ID: WP_001059690.1
• Coordinates: 1199801..1200061 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF742_RS06050 (1195194)	1195194..1195910	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF742_RS06055 (1196058)	1196058..1196480	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF742_RS06060 (1196879)	1196879..1197373	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF742_RS06065 (1197528)	1197528..1198145	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF742_RS06070 (1198218)	1198218..1198799	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF742_RS06075 (1199024)	1199024..1199260	+	237	WP_000368687.1	hypothetical protein	-
IF742_RS06080 (1199257)	1199257..1199460	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF742_RS06085 (1199801)	1199801..1200061	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF742_RS06090 (1200090)	1200090..1200278	+	189	WP_000052076.1	hypothetical protein	Toxin
IF742_RS06095 (1200466)	1200466..1201035	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF742_RS06100 (1201123)	1201123..1201407	+	285	WP_001004394.1	hypothetical protein	-
IF742_RS06105 (1201469)	1201469..1201694	+	226	Protein_1183	hypothetical protein	-
IF742_RS06110 (1202189)	1202189..1202389	-	201	WP_001059082.1	cold-shock protein	-
IF742_RS06115 (1202746)	1202746..1203432	-	687	WP_001566557.1	thermonuclease family protein	-
IF742_RS06120 (1203773)	1203773..1204243	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174413 WP_000052076.1 NZ_CP062340:1200090-1200278 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174413 NZ_CP081007:4466783-4467070 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174413 WP_001059690.1 NZ_CP062340:1199801-1200061 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174413 NZ_CP081007:4466544-4466783 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56