174395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1152999..1153476 Replicon chromosome
Accession NZ_CP062338
Organism Staphylococcus aureus strain NAS_NP_103

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF745_RS05750 Protein ID WP_000052076.1
Coordinates 1153288..1153476 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF745_RS05745 Protein ID WP_001059690.1
Coordinates 1152999..1153259 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF745_RS05710 (1148391) 1148391..1149107 - 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -
IF745_RS05715 (1149255) 1149255..1149678 + 424 Protein_1100 organic hydroperoxide resistance protein -
IF745_RS05720 (1150077) 1150077..1150571 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF745_RS05725 (1150726) 1150726..1151343 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF745_RS05730 (1151416) 1151416..1151997 - 582 WP_001140697.1 histidine phosphatase family protein -
IF745_RS05735 (1152222) 1152222..1152458 + 237 WP_000368687.1 hypothetical protein -
IF745_RS05740 (1152455) 1152455..1152658 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF745_RS05745 (1152999) 1152999..1153259 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF745_RS05750 (1153288) 1153288..1153476 + 189 WP_000052076.1 hypothetical protein Toxin
IF745_RS05755 (1153664) 1153664..1154233 + 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
IF745_RS05760 (1154321) 1154321..1154605 + 285 WP_001004394.1 hypothetical protein -
IF745_RS05765 (1154667) 1154667..1154892 + 226 Protein_1110 hypothetical protein -
IF745_RS05770 (1155387) 1155387..1155587 - 201 WP_001059082.1 cold-shock protein -
IF745_RS05775 (1155944) 1155944..1156630 - 687 WP_001566557.1 thermonuclease family protein -
IF745_RS05780 (1156971) 1156971..1157441 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-88)

Antitoxin

Antitoxin RnlB/LsoB

(14-111)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174395 WP_000052076.1 NZ_CP062338:1153288-1153476 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174395 NZ_CP081007:2557386-2558459 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174395 WP_001059690.1 NZ_CP062338:1152999-1153259 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174395 NZ_CP081007:2558452-2558823 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References