Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1568513..1569289 Replicon chromosome
Accession NZ_CP062336
Organism Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF748_RS07605 Protein ID WP_000031108.1
Coordinates 1568513..1568665 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF748_RS07610 Protein ID WP_001251224.1
Coordinates 1568690..1569289 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF748_RS07590 (1564128) 1564128..1564949 + 822 WP_240029684.1 RluA family pseudouridine synthase -
IF748_RS07595 (1565410) 1565410..1566795 - 1386 WP_000116224.1 class II fumarate hydratase -
IF748_RS07600 (1566991) 1566991..1567386 - 396 WP_000901021.1 hypothetical protein -
IF748_RS07605 (1568513) 1568513..1568665 - 153 WP_000031108.1 SAS053 family protein Toxin
IF748_RS07610 (1568690) 1568690..1569289 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF748_RS07615 (1569447) 1569447..1569917 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF748_RS07620 (1569922) 1569922..1571049 - 1128 WP_000379985.1 tRNA epoxyqueuosine(34) reductase QueG -
IF748_RS07625 (1571200) 1571200..1571922 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF748_RS07630 (1571915) 1571915..1573372 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174377 WP_000031108.1 NZ_CP062336:c1568665-1568513 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174377 NZ_CP080999:c4441295-4440906 [Mycobacterium malmoense]
GTGATGGTTCGGCGGGCCCTCGCCGACACGTCCATCTTCATCGGGATCGAGGCGGCACGATTCGACGACGACCGATTTAC
CGAACACGAGTGGGGCGTCTCGGTGATCACACTGGGTGAGCTGCGGCTGGGTGTCCTGCAAGCCAGTGACCCGGACACCG
CCGCACGCCGGCTCTCCACATACCAGCTTGCTCAGCGGTTCGAACCACTGAGCATCGACGAGACGGTCTCCGAAGCGTGG
GCATTGCTGGTATCCAAGCGCGCCGCCAACCTGCGAGCACCGATCAACGACAGTTGGATTGCGGCAACTGCCATGGCGCA
TGGCATTCCGATCGTGACCCAGGGCAGCGACTACTCTGCGATGCCAGGCGTTGAGGTCATAACAATCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT174377 WP_001251224.1 NZ_CP062336:c1569289-1568690 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174377 NZ_CP080999:c4441549-4441292 [Mycobacterium malmoense]
ATGGCTGCTACGATACCCGCCCGCGATCTCCGTAACCGCACCGCTGAGGTGCTGCGGCGAGTTGCGGCAGGCGAGGAGAT
CGAGGTGCTCAAGGACAACCGTCCTGTGGCGCGCATAGTCCCACTCACACGGCGCCGCCAATGGCTACCGGCAGCGGAGG
TAATCGGCGAACTCATGCGCCTGGGTCCCGATACCACCAACCTCAGCGAGGAACTACGGGAGACGCTGACACGGACCACG
GACGACGTGTCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References