Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 522248..522725 Replicon chromosome
Accession NZ_CP062336
Organism Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF748_RS02620 Protein ID WP_000052076.1
Coordinates 522248..522436 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF748_RS02625 Protein ID WP_001059690.1
Coordinates 522465..522725 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF748_RS02590 (518289) 518289..518759 + 471 WP_000824467.1 hypothetical protein -
IF748_RS02595 (519100) 519100..519786 + 687 WP_001641381.1 thermonuclease family protein -
IF748_RS02600 (520143) 520143..520343 + 201 WP_001059082.1 cold-shock protein -
IF748_RS02605 (520839) 520839..521057 - 219 WP_000005886.1 hypothetical protein -
IF748_RS02610 (521119) 521119..521403 - 285 WP_001004401.1 hypothetical protein -
IF748_RS02615 (521491) 521491..522060 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF748_RS02620 (522248) 522248..522436 - 189 WP_000052076.1 hypothetical protein Toxin
IF748_RS02625 (522465) 522465..522725 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF748_RS02630 (523066) 523066..523269 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
IF748_RS02635 (523266) 523266..523502 - 237 WP_000368687.1 hypothetical protein -
IF748_RS02640 (523727) 523727..524308 + 582 WP_001140693.1 histidine phosphatase family protein -
IF748_RS02645 (524381) 524381..524998 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
IF748_RS02650 (525086) 525086..526732 - 1647 WP_000277718.1 IS1182 family transposase -
IF748_RS02655 (527072) 527072..527566 - 495 WP_000569884.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 525086..526732 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174376 WP_000052076.1 NZ_CP062336:c522436-522248 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174376 NZ_CP080999:4390242-4390640 [Mycobacterium malmoense]
GTGATCGTGGATACTTCGGCGGTCATCGCGATCCTCACAGAAGAGGACGACGCCGCCGTCTACGCCGAGGCCCTTGCCGG
CGCGGACACCTGCAGACTGTCAGCGGCCAGCTACCTCGAATGCGGGATCGTCCTAGATTCCCAGCGTGACCCGATCATTA
GCAGAGCGCTCGATGAACTCATGCAGGAAGCCCAATGCGTAGTCGAGCCGGTAACCGAGCGCCAGGCCCGTCTGGCCCGC
CAAGCGTATGCAGATTTCGGCAAAGGCAGCGGGCACCCGGCGGGTTTGAACTTCGGTGATTGCCTCTCGTACGCGCTGGC
GTCCGACCTACGCGAGCCCCTGCTATGGAAAGGCAACGACTTTGGGTATACGGGCATCAGGTCGGCGCTGGATCAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174376 WP_001059690.1 NZ_CP062336:c522725-522465 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174376 NZ_CP080999:4390000-4390245 [Mycobacterium malmoense]
ATGGCTTTGAACATCAAAGATGCGTCGATCCACGAAGCGGTCAAGCAAATCGCGAAAATCACGGGTGAGTCCCAGACCCA
GGCCGTGGCGACCGCGGTGCAGGAGCGCCTGGCTCGACTGCAACGGGACGATCTCACGGCCCGGATTCTGGCAATCGGCC
ACAAGACTGCGGGCCGGATGAGCTCGGAGACCAAGCAGCTGGACCACGCCACGCTGCTCTACGATCAGCGAGGGCTTCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References