Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2680405..2680919 Replicon chromosome
Accession NZ_CP062334
Organism Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF749_RS13315 Protein ID WP_000581792.1
Coordinates 2680710..2680919 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF749_RS13310 Protein ID WP_000138932.1
Coordinates 2680405..2680698 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF749_RS13290 (2675769) 2675769..2676410 + 642 WP_000483156.1 thiamine phosphate synthase -
IF749_RS13295 (2676496) 2676496..2677368 + 873 WP_000725800.1 membrane protein insertase YidC -
IF749_RS13300 (2678080) 2678080..2678727 - 648 WP_001187630.1 HD domain-containing protein -
IF749_RS13305 (2678755) 2678755..2680239 - 1485 WP_000571549.1 cardiolipin synthase -
IF749_RS13310 (2680405) 2680405..2680698 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF749_RS13315 (2680710) 2680710..2680919 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF749_RS13320 (2681047) 2681047..2681184 + 138 WP_000828354.1 Lmo0850 family protein -
IF749_RS13325 (2681448) 2681448..2682650 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF749_RS13330 (2682968) 2682968..2684038 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF749_RS13335 (2684053) 2684053..2685411 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174371 WP_000581792.1 NZ_CP062334:2680710-2680919 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174371 NZ_CP080999:c3720593-3720174 [Mycobacterium malmoense]
GTGACGGCGCTGCTCGACGTCAATGTCCTTATCGCGTTGAGCTGGCGTAACCATGCTCATCACTCAGCGGCACGGCAGTG
GTTCACGCGGTCTTCGTCGAATGGATGGGCTACCACACCGATCACCGAGGTGGGTTTTGTCCGGATTTCGAGTGATCGCA
GGGTGATGCACGTGTCGACGACTCCGGCGACTGCGCTTGCTCAGTTGGAAGCGCTGAGAGCTCTTCCGGGCCATGCGTTC
TGGCCTGATGACGTGCCGTTGGTGGTTGGTGAAGGGGGTGATCGTGGTGCTGTGTCGAGCCACCGCCTTGTCACCGACTG
TCATCTCATTGCGTTGGTCGCCCGGTACGGTGGCCGGCTGGTCACATTCGACGCTGCACTGGCCGATTCAGCACCCGCCG
GCCTGGTCGAGGTTCTGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174371 WP_000138932.1 NZ_CP062334:2680405-2680698 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174371 NZ_CP080999:c3720814-3720590 [Mycobacterium malmoense]
ATGCGCACTACTCTTCAAATCGATGACGATATCCTTGAAGATGCGCGAAGCATCGCTCGTTCGGAGGGCCGGTCGGTCGG
TGCGGTGATTTCCGATCTGGCGCGTCGGTCGCTTCGGCCCGTCGGGATTGTCGTGGTCGACGGGCTCCCGATGTTCGATG
TGCCGCCAGATGCGCCAATCATCGCCGACGAGGACGTCGCCCGGGGGCTCGAGGAAGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References