Detailed information of TA system TA174362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1193425..1193902
• Replicon: chromosome
• Accession: NZ_CP062334
• Organism: Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF749_RS06075
• Protein ID: WP_000052076.1
• Coordinates: 1193714..1193902 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF749_RS06070
• Protein ID: WP_001059690.1
• Coordinates: 1193425..1193685 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF749_RS06035 (1188818)	1188818..1189534	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF749_RS06040 (1189682)	1189682..1190104	+	423	WP_070001992.1	organic hydroperoxide resistance protein	-
IF749_RS06045 (1190503)	1190503..1190997	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF749_RS06050 (1191152)	1191152..1191769	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF749_RS06055 (1191842)	1191842..1192423	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF749_RS06060 (1192648)	1192648..1192884	+	237	WP_000368687.1	hypothetical protein	-
IF749_RS06065 (1192881)	1192881..1193084	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF749_RS06070 (1193425)	1193425..1193685	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF749_RS06075 (1193714)	1193714..1193902	+	189	WP_000052076.1	hypothetical protein	Toxin
IF749_RS06080 (1194090)	1194090..1194659	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF749_RS06085 (1194747)	1194747..1195031	+	285	WP_001004394.1	hypothetical protein	-
IF749_RS06090 (1195093)	1195093..1195318	+	226	Protein_1178	hypothetical protein	-
IF749_RS06095 (1195813)	1195813..1196013	-	201	WP_001059082.1	cold-shock protein	-
IF749_RS06100 (1196370)	1196370..1197056	-	687	WP_001566557.1	thermonuclease family protein	-
IF749_RS06105 (1197397)	1197397..1197867	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174362 WP_000052076.1 NZ_CP062334:1193714-1193902 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174362 NZ_CP080999:2066635-2066937 [Mycobacterium malmoense]
GTGATCAGCCCGGGCGACATCGTCCCGCGTCGCGGCAGCGACCACGAGCTGTACGTTGTCGTCCTGTCCAACGCGATCCA
TCTCGCCGCCGCTACCGGACGCGTGGTCGCATGCCCTTTCATTCCCGGCCGCGTGCCCGACGACGCGATGGCAATGGTCG
TTGCGGTTCGGCAGCCTGAAGGCACGCTTTTGCCGGAACTTGTGCAGTGGCTCCCACTGTCTGCGCTTGACGAGCCGATT
GGTGCCGTCGGCGCGGCGGCCCTGCGCGAGACCACGACGATCGTGACTGCTCTTATCTCTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174362 WP_001059690.1 NZ_CP062334:1193425-1193685 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174362 NZ_CP080999:2066411-2066638 [Mycobacterium malmoense]
ATGGCGAAGCGGAAGATTTCAGTGACGGTCGACGCGCACATTCTCGCCGCAACCGACGCAAACGCCAGGTCCGCCGGGTT
GAATCGCTCGGAGATGATCGAACAAGCTCTACGCAACGAGCATCTGCGTATCGCCCTGCACAACTACACGAACCGCACCG
TTCCGGCGCTGGACATCGACGCGTACGCGCAGAACGTATATCGGGCGAACCGATCCTCCGGCCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56