Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 91229..92020 Replicon chromosome
Accession NZ_CP062334
Organism Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag IF749_RS00515 Protein ID WP_000525007.1
Coordinates 91229..91693 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag IF749_RS00520 Protein ID WP_000333630.1
Coordinates 91706..92020 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF749_RS00490 (86967) 86967..87497 + 531 WP_240019104.1 acyl-CoA thioesterase -
IF749_RS00495 (87757) 87757..88902 - 1146 WP_001245442.1 radical SAM/CxCxxxxC motif protein YfkAB -
IF749_RS00500 (88947) 88947..89993 - 1047 WP_053865355.1 tyrosine-type recombinase/integrase -
IF749_RS00505 (90106) 90106..90285 + 180 WP_000337827.1 hypothetical protein -
IF749_RS00510 (90265) 90265..91197 - 933 WP_000392183.1 hypothetical protein -
IF749_RS00515 (91229) 91229..91693 - 465 WP_000525007.1 hypothetical protein Toxin
IF749_RS00520 (91706) 91706..92020 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
IF749_RS00525 (92172) 92172..92408 + 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
IF749_RS00530 (92422) 92422..92601 + 180 WP_000438352.1 hypothetical protein -
IF749_RS00535 (92591) 92591..92830 - 240 WP_000438628.1 hypothetical protein -
IF749_RS00540 (92887) 92887..93627 + 741 WP_001148585.1 phage antirepressor KilAC domain-containing protein -
IF749_RS00545 (93652) 93652..93720 + 69 Protein_109 hypothetical protein -
IF749_RS00550 (93741) 93741..94406 - 666 WP_001791529.1 hypothetical protein -
IF749_RS00555 (94478) 94478..94699 + 222 WP_000594790.1 hypothetical protein -
IF749_RS00560 (94692) 94692..94859 + 168 WP_000066013.1 DUF1270 domain-containing protein -
IF749_RS00565 (94860) 94860..95180 + 321 WP_000219666.1 hypothetical protein -
IF749_RS00570 (95274) 95274..95534 + 261 WP_000291075.1 DUF1108 family protein -
IF749_RS00575 (95544) 95544..95765 + 222 WP_000815401.1 DUF2483 family protein -
IF749_RS00580 (95758) 95758..96537 + 780 WP_029052133.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T174358 WP_000525007.1 NZ_CP062334:c91693-91229 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T174358 NZ_CP080999:573135-574019 [Mycobacterium malmoense]
GTGGCCGGCCTTACCCGCGCCCTAGTCGCACGTCATGCGGCTGGACGAGCCGATGCATACGATGCAGCGTTGCTCGACGT
CGCCCAAGATCACCTGCTTTTCCTCCTTGCCCAAGCGGCGAACATCGGTGACGGTCGGCTGGTATTTAAGGGTGGCACTA
GCTTGCGGAAGTGTCGGTTAGGCAACGCTGGCCGATTCTCAATCGACTTAGATTTCGGCGCGCCCGACGACGACGTAGTG
CTCGAGGTCTGCGGCCTTATCGATGGAGCCCGCATCGGTGGCTTTGAATTTGGCATCGTGAGCACCAGGGGTGATGGACG
TCATTGGGGGCTGACGGTCAGTCATGCTGAACTGGGCGCGCCCCGGATTGCAGCCAGTGTCGAATTCGCACGGCGCCCGT
TGGCTCTACCGCCGGAGCCGCTCCCTTTTGTGCCGTTGCCGATCCATAGGGCCTACGGCTTTCCCTTGCCGACGCTGCCA
GTGGTCGCTGAAGCGGAAGCTTGCGCAGAAAAACTTGCGCGATACCGACGCGTCGCTTTGGCACGAGATCTCTACGACTT
GAACCATTTCGCGACTCGCACTTTCGACGAACCTCTTGTGCGGCGCTTATGGGTACTCAAGGTGTGGGCCGACGTGGTTG
ACGATCGACGTGGCGGCCGCCCTCTTCGGCCAGAAGACATCCTCACTGTCCGTGGTGAACAAGACTTCGAGCCCGACTCG
ATTGGGATTTTGACACGGCCCGTCGACATCCCGGACTGGGAAGCCCGCGTTCGACGTCGGTTCGCGTTCCTCACCGACCT
CGACGCGAACGAACAGCGGTGGGCTTCCTGCAACGAACGTCACCGATCGGAAGTGCAAGACGCGCTCTCCGCGCTGCGCG
GTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT174358 WP_000333630.1 NZ_CP062334:c92020-91706 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT174358 NZ_CP080999:572218-573132 [Mycobacterium malmoense]
ATGAACCTAAGCGCGCATGGTGCAACCAGTCCCTTGGGTGCCGACCGGCGCATCCCAAAGTGGGCCTCGGCGGTGATTGG
CGGGCTTGCTCGCGATCGACCGATCGTCGTGACGACCGAAGATCTCGCCCTACGGCTAGCGGAAGCCACCAGTGAGCGCG
ATGTCGATTTAGCAATACGCGACCTACGGCGCCTGGGCTGGCTGGTCGGCCTGCCGGTGCGAGGAACTTGGGCATTCATC
CCGCCAGGAGAGGCTGGCGTGTCCGACCCGTATCTTCCGGTCCGTGCATGGCTAGCGCGTGATCACGACGCAGGCTGCAT
GCTGGCCGGTGCCGCAGCTGCGTGGCATCTCGGGTACCTGGATCGGCAGCCTCAGGGTCGAGTTTCACTGTGGCTTCCAG
CCAAGACGCGACTTCCAGACGGTCTGCGCAAATACGTGTCAATTGTGAAAATCTCCTGGAATATCCAGGACGCTGCGCAG
CTGGCCCCGAGCACGGCGCTGCTCCTCAGACGGCGGCTCGATATCGTGTCGTGGGCGACAGGACTACCCGCGTTTGGCCC
GGAGGCACTGCTTGTGCAGCTCGCCGCGCGCCCATCATCGTTCAGACCATGGGCAGATATCGTCGCGCACCTGGACGTGC
TAGCTGCTGATTGCGTCGATGAGCACCTGCTACCACTTCTTTCGGGCCAGTCGATGTCGACATGGCAACGCGCAAGCTAC
CTGATCGACGTGGCAGGTGACCCTGAACGAGGCGCGGCGCTGCTCGCAAAACGTCAGATGAAGACGATGTCCGTCGTGCA
ATTCACTCATCCGCACATTCGGGCGAGTCGCAGCACCGAGGGCGTCTGGGTTCCGAAATACCAGCTCGTCGATGGTCTCG
TCGCACCGTTGTTATCCGTTGTTGGCAAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References