Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2624105..2624619 Replicon chromosome
Accession NZ_CP062329
Organism Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF761_RS12895 Protein ID WP_000581792.1
Coordinates 2624410..2624619 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF761_RS12890 Protein ID WP_000138932.1
Coordinates 2624105..2624398 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF761_RS12870 (2619709) 2619709..2620350 + 642 WP_000483153.1 thiamine phosphate synthase -
IF761_RS12875 (2620436) 2620436..2621308 + 873 WP_000725802.1 membrane protein insertase YidC -
IF761_RS12880 (2621780) 2621780..2622427 - 648 WP_001187630.1 HD domain-containing protein -
IF761_RS12885 (2622455) 2622455..2623939 - 1485 WP_000571549.1 cardiolipin synthase -
IF761_RS12890 (2624105) 2624105..2624398 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF761_RS12895 (2624410) 2624410..2624619 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF761_RS12900 (2624747) 2624747..2624884 + 138 WP_000828354.1 Lmo0850 family protein -
IF761_RS12905 (2625148) 2625148..2626350 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF761_RS12910 (2626668) 2626668..2627738 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF761_RS12915 (2627753) 2627753..2629111 + 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174334 WP_000581792.1 NZ_CP062329:2624410-2624619 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174334 NZ_CP080960:c3035234-3034833 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174334 WP_000138932.1 NZ_CP062329:2624105-2624398 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174334 NZ_CP080960:c3035481-3035215 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References