Detailed information of TA system TA174334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2624105..2624619
• Replicon: chromosome
• Accession: NZ_CP062329
• Organism: Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: IF761_RS12895
• Protein ID: WP_000581792.1
• Coordinates: 2624410..2624619 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: IF761_RS12890
• Protein ID: WP_000138932.1
• Coordinates: 2624105..2624398 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF761_RS12870 (2619709)	2619709..2620350	+	642	WP_000483153.1	thiamine phosphate synthase	-
IF761_RS12875 (2620436)	2620436..2621308	+	873	WP_000725802.1	membrane protein insertase YidC	-
IF761_RS12880 (2621780)	2621780..2622427	-	648	WP_001187630.1	HD domain-containing protein	-
IF761_RS12885 (2622455)	2622455..2623939	-	1485	WP_000571549.1	cardiolipin synthase	-
IF761_RS12890 (2624105)	2624105..2624398	+	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
IF761_RS12895 (2624410)	2624410..2624619	+	210	WP_000581792.1	heavy metal-associated domain-containing protein	Toxin
IF761_RS12900 (2624747)	2624747..2624884	+	138	WP_000828354.1	Lmo0850 family protein	-
IF761_RS12905 (2625148)	2625148..2626350	-	1203	WP_001109939.1	FtsW/RodA/SpoVE family cell cycle protein	-
IF761_RS12910 (2626668)	2626668..2627738	+	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
IF761_RS12915 (2627753)	2627753..2629111	+	1359	WP_000611470.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T174334 WP_000581792.1 NZ_CP062329:2624410-2624619 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T174334 NZ_CP080960:c3035234-3034833 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT174334 WP_000138932.1 NZ_CP062329:2624105-2624398 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT174334 NZ_CP080960:c3035481-3035215 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• PDB: 6FF1

Antitoxin

• AlphaFold DB: W8UW13