Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2631887..2632401 Replicon chromosome
Accession NZ_CP062326
Organism Staphylococcus aureus strain NAS_OP_043

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag IF764_RS12910 Protein ID WP_000581795.1
Coordinates 2632192..2632401 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag IF764_RS12905 Protein ID WP_000138930.1
Coordinates 2631887..2632180 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF764_RS12885 (2627413) 2627413..2628054 + 642 WP_000483162.1 thiamine phosphate synthase -
IF764_RS12890 (2628140) 2628140..2629012 + 873 WP_000725802.1 membrane protein insertase YidC -
IF764_RS12895 (2629562) 2629562..2630209 - 648 WP_001187625.1 HD domain-containing protein -
IF764_RS12900 (2630237) 2630237..2631721 - 1485 WP_000571562.1 cardiolipin synthase -
IF764_RS12905 (2631887) 2631887..2632180 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF764_RS12910 (2632192) 2632192..2632401 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
IF764_RS12915 (2632528) 2632528..2632665 + 138 WP_000828354.1 Lmo0850 family protein -
IF764_RS12920 (2632929) 2632929..2634131 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF764_RS12925 (2634449) 2634449..2635519 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
IF764_RS12930 (2635534) 2635534..2636892 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T174317 WP_000581795.1 NZ_CP062326:2632192-2632401 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174317 NZ_CP080770:c1945591-1945439 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT174317 WP_000138930.1 NZ_CP062326:2631887-2632180 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174317 NZ_CP080770:c1946215-1945616 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References