Detailed information of TA system TA174314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1168375..1168904
• Replicon: chromosome
• Accession: NZ_CP062326
• Organism: Staphylococcus aureus strain NAS_OP_043

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: IF764_RS05835
• Protein ID: WP_001103939.1
• Coordinates: 1168375..1168692 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: IF764_RS05840
• Protein ID: WP_001058494.1
• Coordinates: 1168695..1168904 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF764_RS13745 (1164000)	1164000..1164134	-	135	WP_256094151.1	hypothetical protein	-
IF764_RS05810 (1164381)	1164381..1165022	-	642	WP_001019808.1	hypothetical protein	-
IF764_RS05815 (1165019)	1165019..1165303	-	285	WP_000998185.1	hypothetical protein	-
IF764_RS05820 (1165305)	1165305..1165667	-	363	WP_001039170.1	hypothetical protein	-
IF764_RS05825 (1165968)	1165968..1167425	-	1458	WP_000390453.1	virulence-associated E family protein	-
IF764_RS05830 (1167442)	1167442..1168311	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
IF764_RS05835 (1168375)	1168375..1168692	-	318	WP_001103939.1	DUF1474 family protein	Toxin
IF764_RS05840 (1168695)	1168695..1168904	-	210	WP_001058494.1	hypothetical protein	Antitoxin
IF764_RS05845 (1168897)	1168897..1169043	-	147	WP_000784885.1	hypothetical protein	-
IF764_RS05850 (1169055)	1169055..1169273	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
IF764_RS05855 (1169309)	1169309..1169512	-	204	WP_001045296.1	transcriptional regulator	-
IF764_RS05860 (1169648)	1169648..1170451	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
IF764_RS05865 (1170441)	1170441..1171547	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
IF764_RS05875 (1172110)	1172110..1172574	-	465	WP_001085185.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sell / sec	1151438..1174968	23530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T174314 WP_001103939.1 NZ_CP062326:c1168692-1168375 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T174314 NZ_CP080770:c858532-858344 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT174314 WP_001058494.1 NZ_CP062326:c1168904-1168695 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT174314 NZ_CP080770:c858821-858561 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59