Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1140304..1140781 Replicon chromosome
Accession NZ_CP062326
Organism Staphylococcus aureus strain NAS_OP_043

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF764_RS05675 Protein ID WP_000052076.1
Coordinates 1140593..1140781 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF764_RS05670 Protein ID WP_001059690.1
Coordinates 1140304..1140564 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF764_RS05635 (1135697) 1135697..1136413 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
IF764_RS05640 (1136561) 1136561..1136983 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
IF764_RS05645 (1137382) 1137382..1137876 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF764_RS05650 (1138032) 1138032..1138649 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
IF764_RS05655 (1138722) 1138722..1139303 - 582 WP_001140696.1 histidine phosphatase family protein -
IF764_RS05660 (1139527) 1139527..1139763 + 237 WP_000368687.1 hypothetical protein -
IF764_RS05665 (1139760) 1139760..1139963 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
IF764_RS05670 (1140304) 1140304..1140564 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF764_RS05675 (1140593) 1140593..1140781 + 189 WP_000052076.1 hypothetical protein Toxin
IF764_RS05680 (1140969) 1140969..1141538 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
IF764_RS05685 (1141626) 1141626..1141898 + 273 WP_001004400.1 hypothetical protein -
IF764_RS05690 (1141971) 1141971..1142189 + 219 WP_000005884.1 hypothetical protein -
IF764_RS05695 (1142686) 1142686..1142886 - 201 WP_001059082.1 cold-shock protein -
IF764_RS05700 (1143243) 1143243..1143929 - 687 WP_001622483.1 thermonuclease family protein -
IF764_RS05705 (1144270) 1144270..1144791 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174313 WP_000052076.1 NZ_CP062326:1140593-1140781 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174313 NZ_CP080769:c16980-16579 [Cupriavidus pinatubonensis]
ATGAAGTACCTGCTCGATGCCAACGCGGTCATCGCGATGCTCAAGGGGGAGCGCATCATGCTGGAGCGCCTGCGCGCGCA
CTTGCCAACCGATTTCGGTCTGCCCTCGATCGTGGCGCATGAACTGTACTATGGCGCCTACAAGAGCCAGCGTGCCGTCG
CGAACCTGGCCCGCATTGAAGCGCTACAGTTCGAAGTCGTGCCGTTCGATGCCGAGGACGCCCAACACGCCGGCGAGATT
CGCGCGCAACTGGCGGCGGCCGGCACCCCGATCGGCCCCTACGACGTGCTGATTGCTGGCCAGGCGAGGGCGCGTAACCT
GATTCTGGTGACCCACAACGTACGCGAATTCGCGCGCGTAGCGCAGCTGAACGTCGAAGATTGGCATGCAGGTGGACAGT
GA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174313 WP_001059690.1 NZ_CP062326:1140304-1140564 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174313 NZ_CP080769:c17219-16977 [Cupriavidus pinatubonensis]
ATGGAGTTCGCCAAGGTTTTCCGACATGGAGGCTCACAGGCGGTGCGGCTGCCCAAGGACTATCGCTTTGACACTGCCGA
GGTGCGCATCCGTCGTCACGGCGCCGCGGTGATTCTCGAGCCCGTGCCGCAGGACTGGGCCTGGCTGGCGCCGCTGGTGG
GGCCGGTCGATGCCGATTTCGAGTCGGCCGCGGTCGCCCAGCCTGAGGCTCAGGAGCGCCCCGGCCTGGATGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References