Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2771320..2771834 Replicon chromosome
Accession NZ_CP062324
Organism Staphylococcus aureus strain NAS_OP_063

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF767_RS13870 Protein ID WP_000581792.1
Coordinates 2771625..2771834 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF767_RS13865 Protein ID WP_000138932.1
Coordinates 2771320..2771613 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF767_RS13845 (2766583) 2766583..2767224 + 642 WP_000483153.1 thiamine phosphate synthase -
IF767_RS13850 (2767310) 2767310..2768182 + 873 WP_000725802.1 membrane protein insertase YidC -
IF767_RS13855 (2768995) 2768995..2769642 - 648 WP_001187629.1 HD domain-containing protein -
IF767_RS13860 (2769670) 2769670..2771154 - 1485 WP_000571549.1 cardiolipin synthase -
IF767_RS13865 (2771320) 2771320..2771613 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF767_RS13870 (2771625) 2771625..2771834 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF767_RS13875 (2771962) 2771962..2772099 + 138 WP_000828354.1 Lmo0850 family protein -
IF767_RS13880 (2772363) 2772363..2773565 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF767_RS13885 (2773883) 2773883..2774953 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF767_RS13890 (2774968) 2774968..2776326 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174306 WP_000581792.1 NZ_CP062324:2771625-2771834 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174306 NZ_CP080760:487292-487642 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174306 WP_000138932.1 NZ_CP062324:2771320-2771613 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174306 NZ_CP080760:487005-487286 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References