Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1217881..1218358 Replicon chromosome
Accession NZ_CP062324
Organism Staphylococcus aureus strain NAS_OP_063

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IF767_RS06225 Protein ID WP_000052078.1
Coordinates 1218170..1218358 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF767_RS06220 Protein ID WP_001059690.1
Coordinates 1217881..1218141 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF767_RS06185 (1213274) 1213274..1213990 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IF767_RS06190 (1214138) 1214138..1214560 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF767_RS06195 (1214959) 1214959..1215453 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF767_RS06200 (1215608) 1215608..1216225 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF767_RS06205 (1216298) 1216298..1216879 - 582 WP_001140686.1 histidine phosphatase family protein -
IF767_RS06210 (1217104) 1217104..1217340 + 237 WP_000368687.1 hypothetical protein -
IF767_RS06215 (1217337) 1217337..1217540 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF767_RS06220 (1217881) 1217881..1218141 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF767_RS06225 (1218170) 1218170..1218358 + 189 WP_000052078.1 hypothetical protein Toxin
IF767_RS06230 (1218546) 1218546..1219115 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF767_RS06235 (1219203) 1219203..1219487 + 285 WP_001004395.1 hypothetical protein -
IF767_RS06240 (1219549) 1219549..1219767 + 219 WP_000005886.1 hypothetical protein -
IF767_RS06245 (1220263) 1220263..1220463 - 201 WP_001059082.1 cold-shock protein -
IF767_RS06250 (1220820) 1220820..1221506 - 687 WP_001548082.1 thermonuclease family protein -
IF767_RS06255 (1221847) 1221847..1222317 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk 1192592..1223674 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(96-155)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T174297 WP_000052078.1 NZ_CP062324:1218170-1218358 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174297 NZ_CP080635:c4231836-4231306 [Shewanella putrefaciens]
GTGAGTTATTCCAAAATTTTCAAAGAATTGGATAAATCACTACACGATAGAGTATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCAAAACATATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGCTATGC
CATTGCCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCTATTGGCAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCGGTTCATAAAGAGTTTCATGG
CAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATATCTGTGGGAAATTAACGCTCACATGAGAGCTTATGCCA
TTGTTGTCGATTGCTTAACTGACCAAGCTGAATCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTCAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174297 WP_001059690.1 NZ_CP062324:1217881-1218141 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174297 NZ_CP080635:c4232102-4231833 [Shewanella putrefaciens]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCATCCGCTTTGCTCGGGTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATGCAACTCAGGTGATAGCTGAGCATGAAAGCGTTACGG
TTAAAGCAGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGTTCCGAATAAGGCATTGCGTGAAGCGGCT
GCATTTACTAAAAATGGTGAGTTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References