Detailed information of TA system TA174280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1197260..1197737
• Replicon: chromosome
• Accession: NZ_CP062322
• Organism: Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF768_RS06085
• Protein ID: WP_000052076.1
• Coordinates: 1197549..1197737 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF768_RS06080
• Protein ID: WP_001059690.1
• Coordinates: 1197260..1197520 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF768_RS06045 (1192653)	1192653..1193369	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF768_RS06050 (1193517)	1193517..1193939	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF768_RS06055 (1194338)	1194338..1194832	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF768_RS06060 (1194987)	1194987..1195604	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF768_RS06065 (1195677)	1195677..1196258	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF768_RS06070 (1196483)	1196483..1196719	+	237	WP_000368687.1	hypothetical protein	-
IF768_RS06075 (1196716)	1196716..1196919	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF768_RS06080 (1197260)	1197260..1197520	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF768_RS06085 (1197549)	1197549..1197737	+	189	WP_000052076.1	hypothetical protein	Toxin
IF768_RS06090 (1197925)	1197925..1198494	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF768_RS06095 (1198582)	1198582..1198866	+	285	WP_001004394.1	hypothetical protein	-
IF768_RS06100 (1198928)	1198928..1199153	+	226	Protein_1177	hypothetical protein	-
IF768_RS06105 (1199648)	1199648..1199848	-	201	WP_001059082.1	cold-shock protein	-
IF768_RS06110 (1200205)	1200205..1200891	-	687	WP_001566557.1	thermonuclease family protein	-
IF768_RS06115 (1201232)	1201232..1201702	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1131061..1211393	80332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-80)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174280 WP_000052076.1 NZ_CP062322:1197549-1197737 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174280 NZ_CP062322:1197549-1197737 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174280 WP_001059690.1 NZ_CP062322:1197260-1197520 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174280 NZ_CP062322:1197260-1197520 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56