Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1175323..1176111 Replicon chromosome
Accession NZ_CP062322
Organism Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag IF768_RS05940 Protein ID WP_000525008.1
Coordinates 1175650..1176111 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag IF768_RS05935 Protein ID WP_000333630.1
Coordinates 1175323..1175637 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF768_RS05880 (1170718) 1170718..1171506 - 789 WP_064266590.1 ATP-binding protein -
IF768_RS05885 (1171499) 1171499..1171720 - 222 WP_015978316.1 DUF2483 family protein -
IF768_RS05890 (1171730) 1171730..1171990 - 261 WP_000291090.1 DUF1108 family protein -
IF768_RS05895 (1172082) 1172082..1172243 - 162 WP_000066017.1 DUF1270 domain-containing protein -
IF768_RS05900 (1172236) 1172236..1172457 - 222 WP_000594789.1 hypothetical protein -
IF768_RS05905 (1172528) 1172528..1173181 + 654 WP_001556705.1 hypothetical protein -
IF768_RS05910 (1173191) 1173191..1173334 - 144 WP_000939498.1 hypothetical protein -
IF768_RS05915 (1173350) 1173350..1174099 - 750 WP_015978301.1 phage antirepressor KilAC domain-containing protein -
IF768_RS05920 (1174159) 1174159..1174641 + 483 WP_000394410.1 hypothetical protein -
IF768_RS05925 (1174742) 1174742..1174921 - 180 WP_000438352.1 hypothetical protein -
IF768_RS05930 (1174935) 1174935..1175171 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
IF768_RS05935 (1175323) 1175323..1175637 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
IF768_RS05940 (1175650) 1175650..1176111 + 462 WP_000525008.1 hypothetical protein Toxin
IF768_RS05945 (1176129) 1176129..1176554 + 426 WP_015967225.1 hypothetical protein -
IF768_RS05950 (1176544) 1176544..1176915 + 372 WP_015967224.1 hypothetical protein -
IF768_RS05955 (1176973) 1176973..1178022 + 1050 WP_001145728.1 tyrosine-type recombinase/integrase -
IF768_RS05960 (1178090) 1178090..1179487 - 1398 WP_001074405.1 Fe-S cluster assembly protein SufB -
IF768_RS05965 (1179638) 1179638..1180102 - 465 WP_001010508.1 SUF system NifU family Fe-S cluster assembly protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1131061..1211393 80332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-62)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18034.35 Da        Isoelectric Point: 4.6899

>T174279 WP_000525008.1 NZ_CP062322:1175650-1176111 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T174279 NZ_CP080626:3262947-3263363 [Pseudomonas sp. S11A 273]
ATGCTCAAGTACATGCTTGATACCAACATCTGCATTTTTACCCTGAAAAACAAACCTCAAGCGATACGTGAAGCATTCAA
CCGCCATCATGGCCAACTCTGCATCAGTACCATTACGCTGATGGAGTTGATCTACGGTGCAGAAAAATCTGCCGCTGCCG
AACGCAATCTGGCCGTGGTCGAAGGCTTTGCCGCTCGCCTGGAGGTCCTCAGCTACGACAGTCATGCAGCGGCACATAGC
GGCCAGCTACGCGCGGAACTGGCCAGGGCTGGAACACCAATTGGCCCCTATGACCAGATGATCGCGGGCCATGCAAGGTC
GCTGGGGCTGCTGTTGGTCACCAACAATATGCGCGAGTTCCAGCGAGTGCCTGGGCTACGCGTAGAGGATTGGCTCAATT
CCTCTGTCCAGCTGTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT174279 WP_000333630.1 NZ_CP062322:1175323-1175637 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT174279 NZ_CP080626:3262716-3262946 [Pseudomonas sp. S11A 273]
ATGGAGCAAGGTGCGGTCTTCAAGAGCAATCGCAGCCAAGCTGTACGCTTGCCCAAATCCGTAGCACTTCCAGAGGATGT
CAAACGCGTGGATGTCGTCGCAGTGGGTCGAACCCGAATCATTTCCCCCGCCGGTGAAACCTGGGACAGCTGGTTTGAAG
GCCCAAGCGTCAGTGCCGACTTCATGGCCGAACGCGAGCAGCCCACCGATCAGGAGCGCGAGGGTTTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References