Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1814557..1815071 Replicon chromosome
Accession NZ_CP062320
Organism Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF771_RS09185 Protein ID WP_000581792.1
Coordinates 1814557..1814766 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF771_RS09190 Protein ID WP_000138932.1
Coordinates 1814778..1815071 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF771_RS09165 (1810065) 1810065..1811423 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF771_RS09170 (1811438) 1811438..1812508 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF771_RS09175 (1812826) 1812826..1814028 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF771_RS09180 (1814292) 1814292..1814429 - 138 WP_000828354.1 Lmo0850 family protein -
IF771_RS09185 (1814557) 1814557..1814766 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF771_RS09190 (1814778) 1814778..1815071 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF771_RS09195 (1815237) 1815237..1816721 + 1485 WP_000571549.1 cardiolipin synthase -
IF771_RS09200 (1816749) 1816749..1817396 + 648 WP_001187629.1 HD domain-containing protein -
IF771_RS09205 (1818209) 1818209..1819081 - 873 WP_000725802.1 membrane protein insertase YidC -
IF771_RS09210 (1819167) 1819167..1819808 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174265 WP_000581792.1 NZ_CP062320:c1814766-1814557 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174265 NZ_CP080620:4108206-4108463 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174265 WP_000138932.1 NZ_CP062320:c1815071-1814778 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174265 NZ_CP080620:4108475-4109020 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References