Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 535869..536346 Replicon chromosome
Accession NZ_CP062320
Organism Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IF771_RS02710 Protein ID WP_000052078.1
Coordinates 535869..536057 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF771_RS02715 Protein ID WP_001059690.1
Coordinates 536086..536346 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF771_RS02680 (531910) 531910..532380 + 471 WP_000824472.1 hypothetical protein -
IF771_RS02685 (532721) 532721..533407 + 687 WP_001548082.1 thermonuclease family protein -
IF771_RS02690 (533764) 533764..533964 + 201 WP_001059082.1 cold-shock protein -
IF771_RS02695 (534460) 534460..534678 - 219 WP_000005886.1 hypothetical protein -
IF771_RS02700 (534740) 534740..535024 - 285 WP_001004395.1 hypothetical protein -
IF771_RS02705 (535112) 535112..535681 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF771_RS02710 (535869) 535869..536057 - 189 WP_000052078.1 hypothetical protein Toxin
IF771_RS02715 (536086) 536086..536346 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF771_RS02720 (536687) 536687..536890 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF771_RS02725 (536887) 536887..537123 - 237 WP_000368687.1 hypothetical protein -
IF771_RS02730 (537348) 537348..537929 + 582 WP_001140686.1 histidine phosphatase family protein -
IF771_RS02735 (538002) 538002..538619 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF771_RS02740 (538774) 538774..539268 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF771_RS02745 (539667) 539667..540089 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF771_RS02750 (540237) 540237..540953 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T174258 WP_000052078.1 NZ_CP062320:c536057-535869 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174258 NZ_CP080620:2773317-2773420 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174258 WP_001059690.1 NZ_CP062320:c536346-536086 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174258 NZ_CP080620:c2773458-2773187 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References