174254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2703921..2704450 Replicon chromosome
Accession NZ_CP062318
Organism Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF775_RS13315 Protein ID WP_001103933.1
Coordinates 2704133..2704450 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag IF775_RS13310 Protein ID WP_001058487.1
Coordinates 2703921..2704130 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF775_RS13275 (2699152) 2699152..2699436 + 285 WP_000917289.1 co-chaperone GroES -
IF775_RS13280 (2699512) 2699512..2701128 + 1617 WP_000240642.1 chaperonin GroEL -
IF775_RS13285 (2701197) 2701197..2702369 - 1173 WP_000179353.1 tyrosine-type recombinase/integrase -
IF775_RS13290 (2702383) 2702383..2703090 - 708 WP_223289515.1 helix-turn-helix transcriptional regulator -
IF775_RS13295 (2703258) 2703258..2703464 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
IF775_RS13300 (2703468) 2703468..2703785 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
IF775_RS13305 (2703782) 2703782..2703928 + 147 WP_000708434.1 hypothetical protein -
IF775_RS13310 (2703921) 2703921..2704130 + 210 WP_001058487.1 hypothetical protein Antitoxin
IF775_RS13315 (2704133) 2704133..2704450 + 318 WP_001103933.1 DUF1474 family protein Toxin
IF775_RS13320 (2704517) 2704517..2705386 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
IF775_RS13325 (2705403) 2705403..2706872 + 1470 WP_001838755.1 virulence-associated E family protein -
IF775_RS13330 (2707158) 2707158..2707520 + 363 WP_001039169.1 hypothetical protein -
IF775_RS13335 (2707522) 2707522..2707806 + 285 WP_000998179.1 hypothetical protein -
IF775_RS13340 (2707803) 2707803..2708444 + 642 WP_001019811.1 hypothetical protein -
IF775_RS13345 (2708980) 2708980..2709321 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T174254 WP_001103933.1 NZ_CP062318:2704133-2704450 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T174254 NZ_CP080620:2469889-2469996 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT174254 WP_001058487.1 NZ_CP062318:2703921-2704130 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174254 NZ_CP080620:c2469841-2469774 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References