Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2651839..2652368 Replicon chromosome
Accession NZ_CP062318
Organism Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF775_RS13040 Protein ID WP_000621175.1
Coordinates 2652006..2652368 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF775_RS13035 Protein ID WP_000948331.1
Coordinates 2651839..2652009 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF775_RS13005 (2646875) 2646875..2647435 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
IF775_RS13010 (2647644) 2647644..2648123 + 480 WP_001287079.1 hypothetical protein -
IF775_RS13015 (2648116) 2648116..2649699 + 1584 WP_001294620.1 PH domain-containing protein -
IF775_RS13020 (2649686) 2649686..2650177 + 492 WP_001205912.1 PH domain-containing protein -
IF775_RS13025 (2650181) 2650181..2650540 + 360 WP_000581197.1 holo-ACP synthase -
IF775_RS13030 (2650606) 2650606..2651754 + 1149 WP_001281154.1 alanine racemase -
IF775_RS13035 (2651839) 2651839..2652009 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF775_RS13040 (2652006) 2652006..2652368 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF775_RS13045 (2652718) 2652718..2653719 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF775_RS13050 (2653838) 2653838..2654164 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF775_RS13055 (2654166) 2654166..2654645 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF775_RS13060 (2654620) 2654620..2655390 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174253 WP_000621175.1 NZ_CP062318:2652006-2652368 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174253 NZ_CP080620:2469354-2469461 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174253 WP_000948331.1 NZ_CP062318:2651839-2652009 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174253 NZ_CP080620:c2469306-2469239 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References