Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2632096..2632610 Replicon chromosome
Accession NZ_CP062318
Organism Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF775_RS12950 Protein ID WP_000581792.1
Coordinates 2632401..2632610 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF775_RS12945 Protein ID WP_000138932.1
Coordinates 2632096..2632389 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF775_RS12925 (2627460) 2627460..2628101 + 642 WP_000483156.1 thiamine phosphate synthase -
IF775_RS12930 (2628187) 2628187..2629059 + 873 WP_000725800.1 membrane protein insertase YidC -
IF775_RS12935 (2629771) 2629771..2630418 - 648 WP_001187630.1 HD domain-containing protein -
IF775_RS12940 (2630446) 2630446..2631930 - 1485 WP_000571549.1 cardiolipin synthase -
IF775_RS12945 (2632096) 2632096..2632389 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF775_RS12950 (2632401) 2632401..2632610 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF775_RS12955 (2632738) 2632738..2632875 + 138 WP_000828354.1 Lmo0850 family protein -
IF775_RS12960 (2633139) 2633139..2634341 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF775_RS12965 (2634659) 2634659..2635729 + 1071 WP_042908004.1 D-alanine--D-alanine ligase -
IF775_RS12970 (2635744) 2635744..2637102 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174252 WP_000581792.1 NZ_CP062318:2632401-2632610 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174252 NZ_CP080620:c1929325-1928990 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174252 WP_000138932.1 NZ_CP062318:2632096-2632389 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174252 NZ_CP080620:c1929573-1929325 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References