Detailed information of TA system TA174243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1152201..1152678
• Replicon: chromosome
• Accession: NZ_CP062318
• Organism: Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF775_RS05740
• Protein ID: WP_000052076.1
• Coordinates: 1152490..1152678 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF775_RS05735
• Protein ID: WP_001059690.1
• Coordinates: 1152201..1152461 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF775_RS05700 (1147594)	1147594..1148310	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF775_RS05705 (1148458)	1148458..1148880	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF775_RS05710 (1149279)	1149279..1149773	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF775_RS05715 (1149928)	1149928..1150545	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF775_RS05720 (1150618)	1150618..1151199	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF775_RS05725 (1151424)	1151424..1151660	+	237	WP_000368687.1	hypothetical protein	-
IF775_RS05730 (1151657)	1151657..1151860	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF775_RS05735 (1152201)	1152201..1152461	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF775_RS05740 (1152490)	1152490..1152678	+	189	WP_000052076.1	hypothetical protein	Toxin
IF775_RS05745 (1152866)	1152866..1153435	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF775_RS05750 (1153523)	1153523..1153807	+	285	WP_001004394.1	hypothetical protein	-
IF775_RS05755 (1153869)	1153869..1154094	+	226	Protein_1109	hypothetical protein	-
IF775_RS05760 (1154589)	1154589..1154789	-	201	WP_001059082.1	cold-shock protein	-
IF775_RS05765 (1155146)	1155146..1155832	-	687	WP_001566557.1	thermonuclease family protein	-
IF775_RS05770 (1156173)	1156173..1156643	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174243 WP_000052076.1 NZ_CP062318:1152490-1152678 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174243 NZ_CP080597:c5643463-5643149 [Pseudomonas sp. ERGC3:05]
GTGATATTTGTCGAATCACCCGTATTTACCGAGGACCTGCCAGCGCTACTGAGTGAGGAAAGCTACGGTGAGTTCCAGGA
ATTTCTTGCCGAAAACCCGACTGCTGGTGATGTCATCCAAGGGACCAATGGTCTGAGAAAGATCCGCTGGGCTCTGCAGG
GGAGGGGCAAGAGGGGTGGTGTCAGAGTGATCTATTACCACCTCTGCATGGCCTATCAAATTCGATTGATCCTGATCTAT
CGAAAGGGCATCAAAGATGATCTCTCTGCGGTGGAAAAGAGCGTGCTGAGCGAAATTAACCGAAGGTGGGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174243 WP_001059690.1 NZ_CP062318:1152201-1152461 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174243 NZ_CP080597:c5643149-5642856 [Pseudomonas sp. ERGC3:05]
ATGGAGAAAAAACTGTTCAATCGTCTGGTCGAAAGCATGACCCAGATGGACGAAATCGCACGGGGTGAGCGCGCCCCATC
CCGCGAATTTTTTGTTGATGCGTTGAAGGTAAAAGAGATTCGACAAGCCACAGGACTTTCACAAGCACGCTTTGCGAAGG
CAATTGATGTGCCGGTGGGAACGCTTCAAAACTGGGAGCAGGGGCGACGTGAACCAGAGGGGCCGGCAAAGGCATTATTG
CGTGCCTTATACAATGATCCGGATCACGTATTGGCCGCTCTGGGGCATCGATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56