Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1212218..1212695 Replicon chromosome
Accession NZ_CP062314
Organism Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IF776_RS06130 Protein ID WP_000052078.1
Coordinates 1212507..1212695 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF776_RS06125 Protein ID WP_001059690.1
Coordinates 1212218..1212478 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF776_RS06090 (1207611) 1207611..1208327 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IF776_RS06095 (1208475) 1208475..1208897 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF776_RS06100 (1209296) 1209296..1209790 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF776_RS06105 (1209945) 1209945..1210562 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF776_RS06110 (1210635) 1210635..1211216 - 582 WP_001140686.1 histidine phosphatase family protein -
IF776_RS06115 (1211441) 1211441..1211677 + 237 WP_000368687.1 hypothetical protein -
IF776_RS06120 (1211674) 1211674..1211877 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF776_RS06125 (1212218) 1212218..1212478 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF776_RS06130 (1212507) 1212507..1212695 + 189 WP_000052078.1 hypothetical protein Toxin
IF776_RS06135 (1212883) 1212883..1213452 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF776_RS06140 (1213540) 1213540..1213824 + 285 WP_001004395.1 hypothetical protein -
IF776_RS06145 (1213886) 1213886..1214104 + 219 WP_000005886.1 hypothetical protein -
IF776_RS06150 (1214600) 1214600..1214800 - 201 WP_001059082.1 cold-shock protein -
IF776_RS06155 (1215157) 1215157..1215843 - 687 WP_001548082.1 thermonuclease family protein -
IF776_RS06160 (1216184) 1216184..1216654 - 471 WP_239794888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T174225 WP_000052078.1 NZ_CP062314:1212507-1212695 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174225 NZ_CP080591:3852178-3852453 [Cronobacter sakazakii]
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174225 WP_001059690.1 NZ_CP062314:1212218-1212478 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174225 NZ_CP080591:3851868-3852173 [Cronobacter sakazakii]
ATGAAGCATATTTTTCAAACTGAAGTATTCCGCCGCTGGCAAGCCAGTCTGAAAGACCAGCGGGTAAAAACGATGATTGC
CGCGCGGCTTTTTCGGCTGGCTAATGGTTTGCCTGGTGATGTTAAGCCCGTCGGCGCAGGCATCAGTGAACTGCGTATTC
ACTACGGCGCGGGATACCGGATTTATTTCAAACAACACGGCGAGGTGATTGTCATTTTGCTTTGTGGTGGTGATAAGCAC
ACGCAGGATAAAGACATTCTTCTTGCGAAAATGCTGGCTGACCTGCCAGAGAACCAGTGGAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References