Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2722544..2723073 Replicon chromosome
Accession NZ_CP062312
Organism Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF782_RS13510 Protein ID WP_000621175.1
Coordinates 2722711..2723073 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF782_RS13505 Protein ID WP_000948331.1
Coordinates 2722544..2722714 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF782_RS13475 (2717580) 2717580..2718140 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IF782_RS13480 (2718349) 2718349..2718828 + 480 WP_001287088.1 hypothetical protein -
IF782_RS13485 (2718821) 2718821..2720404 + 1584 WP_001294626.1 PH domain-containing protein -
IF782_RS13490 (2720391) 2720391..2720882 + 492 WP_001205910.1 PH domain-containing protein -
IF782_RS13495 (2720886) 2720886..2721245 + 360 WP_000581200.1 holo-ACP synthase -
IF782_RS13500 (2721311) 2721311..2722459 + 1149 WP_001281145.1 alanine racemase -
IF782_RS13505 (2722544) 2722544..2722714 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF782_RS13510 (2722711) 2722711..2723073 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF782_RS13515 (2723423) 2723423..2724424 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF782_RS13520 (2724543) 2724543..2724869 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF782_RS13525 (2724871) 2724871..2725350 + 480 WP_001190830.1 anti-sigma B factor RsbW -
IF782_RS13530 (2725325) 2725325..2726095 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174218 WP_000621175.1 NZ_CP062312:2722711-2723073 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174218 NZ_CP080591:c2533272-2533169 [Cronobacter sakazakii]
GGCAAGGCGACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174218 WP_000948331.1 NZ_CP062312:2722544-2722714 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174218 NZ_CP080591:2533166-2533334 [Cronobacter sakazakii]
GATAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAGTCGCCTTGCCTTTTAAGAATAGATGACGACACCAGCTTTTCCAGTTTGCGGCTAAAGTCGCAG
CAAAAAGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References