Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2702818..2703332 Replicon chromosome
Accession NZ_CP062312
Organism Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF782_RS13420 Protein ID WP_000581792.1
Coordinates 2703123..2703332 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF782_RS13415 Protein ID WP_000138932.1
Coordinates 2702818..2703111 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF782_RS13395 (2698422) 2698422..2699063 + 642 WP_000483153.1 thiamine phosphate synthase -
IF782_RS13400 (2699149) 2699149..2700021 + 873 WP_000725802.1 membrane protein insertase YidC -
IF782_RS13405 (2700493) 2700493..2701140 - 648 WP_001187629.1 HD domain-containing protein -
IF782_RS13410 (2701168) 2701168..2702652 - 1485 WP_000571549.1 cardiolipin synthase -
IF782_RS13415 (2702818) 2702818..2703111 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF782_RS13420 (2703123) 2703123..2703332 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF782_RS13425 (2703460) 2703460..2703597 + 138 WP_000828354.1 Lmo0850 family protein -
IF782_RS13430 (2703861) 2703861..2705063 - 1203 WP_001109941.1 FtsW/RodA/SpoVE family cell cycle protein -
IF782_RS13435 (2705381) 2705381..2706451 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF782_RS13440 (2706466) 2706466..2707824 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174217 WP_000581792.1 NZ_CP062312:2703123-2703332 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174217 NZ_CP080591:2098996-2099274 [Cronobacter sakazakii]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCTCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGACCCGCTGACGTCGACTTACCGGGATTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTTATCGTCAACTATGAGGATTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174217 WP_000138932.1 NZ_CP062312:2702818-2703111 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174217 NZ_CP080591:2099274-2099561 [Cronobacter sakazakii]
ATGGCAACGATGTTTAACCCACCGCACCCGGGCAGGCTGGTGCAGGAGTCAATGGAAGCGCTCGGCCTCAGTGCCCGTGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCGACGGTGCAGCGTCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAAAACGAATACGATCTCTTTCAGGCG
CGCCAGTCTGTTGATTTCTCGCACCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References