Detailed information of TA system TA174208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1236077..1236606
• Replicon: chromosome
• Accession: NZ_CP062312
• Organism: Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: IF782_RS06255
• Protein ID: WP_001103939.1
• Coordinates: 1236077..1236394 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: IF782_RS06260
• Protein ID: WP_001058494.1
• Coordinates: 1236397..1236606 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF782_RS06230 (1232083)	1232083..1232724	-	642	WP_001019808.1	hypothetical protein	-
IF782_RS06235 (1232721)	1232721..1233005	-	285	WP_000998185.1	hypothetical protein	-
IF782_RS06240 (1233007)	1233007..1233369	-	363	WP_001039170.1	hypothetical protein	-
IF782_RS06245 (1233670)	1233670..1235127	-	1458	WP_000390453.1	virulence-associated E family protein	-
IF782_RS06250 (1235144)	1235144..1236013	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
IF782_RS06255 (1236077)	1236077..1236394	-	318	WP_001103939.1	DUF1474 family protein	Toxin
IF782_RS06260 (1236397)	1236397..1236606	-	210	WP_001058494.1	hypothetical protein	Antitoxin
IF782_RS06265 (1236599)	1236599..1236745	-	147	WP_000784885.1	hypothetical protein	-
IF782_RS06270 (1236757)	1236757..1236975	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
IF782_RS06275 (1237011)	1237011..1237214	-	204	WP_001045296.1	transcriptional regulator	-
IF782_RS06280 (1237350)	1237350..1238153	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
IF782_RS06285 (1238143)	1238143..1239249	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
IF782_RS06295 (1239812)	1239812..1240276	-	465	WP_001085186.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	1206249..1239249	33000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T174208 WP_001103939.1 NZ_CP062312:c1236394-1236077 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T174208 NZ_CP080589:c934386-933826 [Xanthomonas oryzae pv. oryzicola]
CTGCACTGTGGTAATGCCGCTGTGCAGAGTTCGAGTTGGGTGAGCATCGGCAACCCAGAACTGATCGACAAGCGCTCCAG
TCATCCTGTACCGCGTCCACCGGGCGGCTTCTCAAACGATTACGTGCCGTTCTACTTCACTCCGTTTTTGCCGATGCTGC
GCAACATCCATACCGCCTGGGGTGGAATCCAAAGGCGGCCTAACGAAGACATCGTCATCCTTGTTTCCAGCTTGCATCAT
GTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTCCGATTTATC
CGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCAAGTTCGAGC
GCTATCAGGCCGAGGCCCTGATTCACCGACACGTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACGGATGGTTTG
CAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGGGTGGTATTTCCGATG
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT174208 WP_001058494.1 NZ_CP062312:c1236606-1236397 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT174208 NZ_CP080589:c933829-932756 [Xanthomonas oryzae pv. oryzicola]
ATGATCACGTTCACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGGATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACCGGGCCGACGTGCGCCCACTGATCGAAG
AAGTACTAGCAGGTTTGGATACAGACATCCTCGTGTTCGAGCCTACCTTGAAGTATCAGAACGTTGCCAAGCGCTCCGGC
GTGGAAAAATTGACCCCGGCACGCGCCTTGATTGCCGAGCTGGTACGTCGTTACTGGGTGCTAGGTATGGAATGCGGCCT
GTTGGAAATCCAGAAACTGGCGTGGTTCCTTGAACGCAACATCGAGCGAGCGGGCTTGCCTGAGCTTGATTTGCGCTTTT
CAGCACACAAGTACGGCCCTTATGCCGACCGTCTACGCCATCTTCTGAACGGGCTGGACGGAAGCTACCTGCATTGTGAC
AAACGGATCAGCGACGCCGACCCGCTGGACGTGATCTGGTTCGACGACAATCGCAAAAGCTTCGTACAGACCTACCTACT
AAAGAGCGAGGCGAAACAGTACATTCCAGCACTGGAAGCTACTGCCGCCTTGATCGATGGTTTTGAATCTCCTTTTGGCA
TGGAGTTGTTGGCGACAGTTGACTGGCTGATTGTGCAGGAAGGTATCTCTGCGCAAGTTGCCGACGTGCGTGAAGGCATA
CGCCACTGGCCAGGTGATCAGGAGGCAGCGGCGCGAAAGGACAGACTGTTCGATGACCGCGCCTTGGGGATCGCGCTGAA
ACGACTGGCATCAGGTGCAATCGCAGTGGCTTAA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59