Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1209171..1209648 Replicon chromosome
Accession NZ_CP062312
Organism Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF782_RS06100 Protein ID WP_000052076.1
Coordinates 1209460..1209648 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF782_RS06095 Protein ID WP_001059690.1
Coordinates 1209171..1209431 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF782_RS06060 (1204564) 1204564..1205280 - 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -
IF782_RS06065 (1205428) 1205428..1205850 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
IF782_RS06070 (1206249) 1206249..1206743 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF782_RS06075 (1206898) 1206898..1207515 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF782_RS06080 (1207588) 1207588..1208169 - 582 WP_239794378.1 histidine phosphatase family protein -
IF782_RS06085 (1208394) 1208394..1208630 + 237 WP_000368687.1 hypothetical protein -
IF782_RS06090 (1208627) 1208627..1208830 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF782_RS06095 (1209171) 1209171..1209431 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF782_RS06100 (1209460) 1209460..1209648 + 189 WP_000052076.1 hypothetical protein Toxin
IF782_RS06105 (1209836) 1209836..1210405 + 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
IF782_RS06110 (1210493) 1210493..1210777 + 285 WP_001004399.1 hypothetical protein -
IF782_RS06115 (1210839) 1210839..1211057 + 219 WP_000005884.1 hypothetical protein -
IF782_RS06120 (1211552) 1211552..1211752 - 201 WP_001059082.1 cold-shock protein -
IF782_RS06125 (1212109) 1212109..1212795 - 687 WP_000141557.1 thermonuclease family protein -
IF782_RS06130 (1213136) 1213136..1213657 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec 1206249..1239249 33000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(149-291)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174207 WP_000052076.1 NZ_CP062312:1209460-1209648 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174207 NZ_CP080589:645261-646526 [Xanthomonas oryzae pv. oryzicola]
ATGAAAAACAAGACAGACATTGCTGGCATAGCCGGACTTTCTACGTCTCATGTTTCCTTTGATGACGCAGAATCCAAAAG
CGTCCTAGATGGATCAACACAGTCTACGCCGGAGTACAAATTCCAGACCCCGCTTGATCAGTTGCCGGCTAGGCCCGCTG
GTCCGAAGAGCAGTAACACAACTGATGCTTACATTCATGAATCACTGCCGCATTCGGTTCCAATCGCAGGTGCATCGACC
TCCGCGGTGACACATCAACAGGCTACTCAGCGTAAAGGCACCGATGAGATCTATGGTTTGGGCAGCCTCCCATCTGCTGG
TCCAGAGCGATGGGATTATCTTGCGAATCCGGGGAACTGGCATCCCGAACGCCGTAAGTTACACGAAAAGCTATTAGATC
AAGCGCGATCTTCTGCCTTGACCCTGGCAGAATCCCTTGAGAGTGATGGCTGCCAACCGACATTGTTTGCGCTGCGCGGA
AATACCGCAACGGGTAAAACACGGATTGCGACAAAAAAGATCCCGGTGCTCGCAGCAGCTCTGAAGAAGACAGGTGGGAA
AGGTTGCGTGAATCCAGATGTATTCAAGAGTTCGCTTGCGAAATCCGAGGCAGGCGCCAAGATATTTAGTTCGGCACAAG
TGCATAGCGAGTCATCTTTTCTTGCCGACCGGTTTGAAGGCGGACTTCGCTCTCAAAAGACGGGCAGCGGTGCAATCGCT
AGCATTGTTGTCGACAAGCGCTTGTCAAGAGCGTACGAAATTGATAGCTACATACAACTAGCGAAAGAAACCGGTAGAAA
AGTGGAATTGTGCGATATCGACGCGCCCCTAGAGAATTCTTTGGTGGGAGTTTTGCAGCGAAAACCGGAAGGTGAAGATC
CTAGGCCTCCGTACCCTGTAGTCTCGAGTGGATTTGTAGCCGTACGGAGCAATAGAATGTACGTGATAGACAGGTTCATT
GCCGATCCGAGCCTGGGAAACTACCGACTATTCGGAACAGCTGAAGATGGTGAGAAGGTCATGGTTGCTACCGTGATTGG
CGGTGAGTTTAGTGTAGAGAATGCTGAGTTGTATGAAAAAATCACGTCCCCACAGCTCTCGGTTACGGGCGATTTGGCTG
ATAAGGTAATCGACAAGGAATTGATTGATCGTCTGAAAAATAATATAGCTGACCCCGAGCGGGCGGCCAAGACGCAAGCC
GCCCTGGAAAAATACAGCGGTAAGTCATGGTCGGCCGCGCTAGCTGCTCACAGCGAGCTAATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174207 WP_001059690.1 NZ_CP062312:1209171-1209431 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174207 NZ_CP080589:646544-646840 [Xanthomonas oryzae pv. oryzicola]
ATGAAAACTTTGACAGGCGCAGACGCACTCGAATTTCATAAGAAGCTTAAGGAACGTAATAAAGCCTTACATGCTTCCGA
CCTCGAGTTAGCACTGGTGCACGCCGATGCTGTCGGCAAAGAACGGTTCGATCTCGAGGAGCTGGAGAAAATTTGCGATA
CCAGCGATGCGGGGCGCCTTACTGATGCGAAAGAGCGACACGACATATATGAACGGATGTACTACGTTGAGTATCCCAAC
GTTATGACGTTAAAGGAATTCGCTCATATCGTCGAGACACTTTCCTCGTGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References