Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 51627..52285 Replicon plasmid pXAC64
Accession NZ_CP062256
Organism Xanthomonas sp. gxlp16

Toxin (Protein)


Gene name vapC Uniprot ID Q8PRH3
Locus tag IG630_RS22355 Protein ID WP_011053002.1
Coordinates 51627..52028 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U2L0
Locus tag IG630_RS22360 Protein ID WP_011053003.1
Coordinates 52025..52285 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG630_RS22335 47067..47834 - 768 WP_011052998.1 ParA family protein -
IG630_RS22340 48639..49865 - 1227 WP_015472949.1 plasmid replication initiator protein -
IG630_RS22345 50145..51332 - 1188 WP_011053001.1 zeta toxin family protein -
IG630_RS22350 51339..51602 - 264 WP_005917846.1 hypothetical protein -
IG630_RS22355 51627..52028 - 402 WP_011053002.1 type II toxin-antitoxin system VapC family toxin Toxin
IG630_RS22360 52025..52285 - 261 WP_011053003.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IG630_RS22365 52476..53048 + 573 WP_011053004.1 recombinase family protein -
IG630_RS22370 53079..53666 - 588 Protein_60 IS3-like element ISXac3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64919 64919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(8-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14627.05 Da        Isoelectric Point: 7.2785

>T174187 WP_011053002.1 NZ_CP062256:c52028-51627 [Xanthomonas sp. WG16]
MKRYMLDTNTVSHLVKSHPAVSRRVIEVPMTALCMSAITGGELMFGLAKVPDAKRLQQAVMELLRRVDVLPWDGAVMERY
GSVRADLEKQGKALGSLDMLIAAHALETDSVLVTNDAAFSRVVGLTVEDWTRS

Download         Length: 402 bp

>T174187 NZ_CP080566:c2597646-2597539 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9799.00 Da        Isoelectric Point: 5.0941

>AT174187 WP_011053003.1 NZ_CP062256:c52285-52025 [Xanthomonas sp. WG16]
VSQVAKLFINGRSQAVRLPAAYRFTEKEVFIRQDPETGDVILSRKPATWEDFFIVLKSADVPANFLDAAERNQGTQDRDP
FAGWRE

Download         Length: 261 bp

>AT174187 NZ_CP080566:2597462-2597522 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8PRH3

Antitoxin

Source ID Structure
AlphaFold DB M4U2L0

References