174185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5072267..5072934 Replicon chromosome
Accession NZ_CP062255
Organism Xanthomonas sp. gxlp16

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag IG630_RS21770 Protein ID WP_005916679.1
Coordinates 5072518..5072934 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag IG630_RS21765 Protein ID WP_005916676.1
Coordinates 5072267..5072521 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG630_RS21740 5068389..5068608 + 220 Protein_4248 RNA 2'-phosphotransferase -
IG630_RS21745 5068765..5070030 + 1266 WP_015463799.1 cardiolipin synthase B -
IG630_RS21750 5070056..5070583 - 528 WP_005916668.1 hypothetical protein -
IG630_RS21755 5070822..5071028 + 207 WP_003489327.1 hypothetical protein -
IG630_RS21760 5071015..5072121 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
IG630_RS21765 5072267..5072521 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
IG630_RS21770 5072518..5072934 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
IG630_RS21775 5073056..5073259 - 204 WP_125460668.1 hypothetical protein -
IG630_RS21780 5073387..5073599 - 213 WP_015472901.1 hypothetical protein -
IG630_RS21785 5073856..5075475 + 1620 WP_015463800.1 hypothetical protein -
IG630_RS21790 5075579..5075977 - 399 WP_004429277.1 DUF2384 domain-containing protein -
IG630_RS21795 5076293..5076724 + 432 WP_005922907.1 hypothetical protein -
IG630_RS21800 5076753..5077079 - 327 Protein_4260 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T174185 WP_005916679.1 NZ_CP062255:5072518-5072934 [Xanthomonas sp. WG16]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T174185 NZ_CP080566:c2306192-2306088 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT174185 WP_005916676.1 NZ_CP062255:5072267-5072521 [Xanthomonas sp. WG16]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT174185 NZ_CP080566:2305976-2306031 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References