Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4672984..4673345 Replicon chromosome
Accession NZ_CP062255
Organism Xanthomonas sp. gxlp16

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag IG630_RS20195 Protein ID WP_005914328.1
Coordinates 4672984..4673118 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag IG630_RS20200 Protein ID WP_003486606.1
Coordinates 4673193..4673345 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG630_RS20175 4668122..4669813 - 1692 WP_015471463.1 M20/M25/M40 family metallo-hydrolase -
IG630_RS20180 4670005..4671039 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
IG630_RS20185 4671078..4672367 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
IG630_RS20190 4672548..4672757 - 210 WP_003486601.1 CsbD family protein -
IG630_RS20195 4672984..4673118 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
IG630_RS20200 4673193..4673345 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
IG630_RS20205 4673452..4674375 - 924 WP_005927745.1 arginase -
IG630_RS20210 4674696..4675148 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
IG630_RS20215 4675212..4675571 + 360 WP_003486613.1 hypothetical protein -
IG630_RS20220 4675668..4676585 + 918 WP_011052673.1 hypothetical protein -
IG630_RS20225 4676582..4677124 + 543 WP_003486615.1 GTPase -
IG630_RS20230 4677562..4678245 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T174184 WP_005914328.1 NZ_CP062255:c4673118-4672984 [Xanthomonas sp. WG16]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T174184 NZ_CP080566:c2248796-2248587 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT174184 WP_003486606.1 NZ_CP062255:c4673345-4673193 [Xanthomonas sp. WG16]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT174184 NZ_CP080566:c2249101-2248808 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References