Detailed information of TA system TA174183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2840410..2840966
• Replicon: chromosome
• Accession: NZ_CP062255
• Organism: Xanthomonas sp. gxlp16

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IG630_RS12495
• Protein ID: WP_011051576.1
• Coordinates: 2840410..2840700 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: IG630_RS12500
• Protein ID: WP_004541313.1
• Coordinates: 2840688..2840966 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG630_RS12465	2835721..2835861	-	141	WP_157860651.1	hypothetical protein	-
IG630_RS12470	2836147..2837103	-	957	WP_011051571.1	hypothetical protein	-
IG630_RS12475	2837170..2838303	-	1134	Protein_2431	IS5 family transposase	-
IG630_RS12480	2838343..2839430	-	1088	Protein_2432	IS3 family transposase	-
IG630_RS12485	2839643..2839822	-	180	WP_015463309.1	hypothetical protein	-
IG630_RS12490	2840093..2840413	-	321	WP_099522003.1	hypothetical protein	-
IG630_RS12495	2840410..2840700	-	291	WP_011051576.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IG630_RS12500	2840688..2840966	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
IG630_RS12505	2841136..2842404	-	1269	Protein_2437	transposase	-
IG630_RS12510	2842453..2843678	+	1226	Protein_2438	IS3 family transposase	-
IG630_RS12515	2844314..2845252	+	939	WP_043930788.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2832580..2859100	26520
	-	inside	IScluster/Tn	-	-	2837170..2843678	6508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10831.41 Da
• Isoelectric Point: 9.9308

>T174183 WP_011051576.1 NZ_CP062255:c2840700-2840410 [Xanthomonas sp. WG16]
MPQVIFAPAAIGDMQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T174183 NZ_CP080566:c2227690-2227328 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT174183 WP_004541313.1 NZ_CP062255:c2840966-2840688 [Xanthomonas sp. WG16]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT174183 NZ_CP080566:c2227857-2227687 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0