Detailed information of TA system TA174182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2573242..2573875
• Replicon: chromosome
• Accession: NZ_CP062255
• Organism: Xanthomonas sp. gxlp16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IG630_RS11280
• Protein ID: WP_015463212.1
• Coordinates: 2573242..2573655 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: IG630_RS11285
• Protein ID: WP_015463213.1
• Coordinates: 2573642..2573875 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG630_RS11265	2568934..2571114	+	2181	WP_011051394.1	TonB-dependent siderophore receptor	-
IG630_RS11270	2571323..2572837	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
IG630_RS11275	2572853..2573215	-	363	WP_015463211.1	DUF3742 family protein	-
IG630_RS11280	2573242..2573655	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
IG630_RS11285	2573642..2573875	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IG630_RS11290	2574133..2575164	+	1032	WP_194163849.1	DUF4917 family protein	-
IG630_RS11295	2575297..2575695	-	399	WP_099521978.1	hypothetical protein	-
IG630_RS11300	2576147..2576722	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
IG630_RS11305	2576703..2577752	+	1050	WP_011051401.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T174182 WP_015463212.1 NZ_CP062255:c2573655-2573242 [Xanthomonas sp. WG16]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T174182 NZ_CP080566:c2175507-2175181 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT174182 WP_015463213.1 NZ_CP062255:c2573875-2573642 [Xanthomonas sp. WG16]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT174182 NZ_CP080566:c2175695-2175510 [Staphylococcus aureus]
ATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGG
TATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATA
ATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: M4TWF0