Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3699462..3699988 Replicon chromosome
Accession NZ_CP062254
Organism Pectobacterium parmentieri strain QK-5

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag IG623_RS16970 Protein ID WP_103808718.1
Coordinates 3699683..3699988 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID E0SK21
Locus tag IG623_RS16965 Protein ID WP_012773205.1
Coordinates 3699462..3699680 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG623_RS16935 3694538..3695425 - 888 WP_116164987.1 ParA family protein -
IG623_RS16940 3695685..3696944 + 1260 WP_103808713.1 integrase arm-type DNA-binding domain-containing protein -
IG623_RS16945 3697051..3697245 - 195 WP_103808714.1 DUF3950 domain-containing protein -
IG623_RS16950 3697431..3697772 + 342 WP_103808715.1 hypothetical protein -
IG623_RS16955 3698217..3698540 - 324 WP_162940689.1 hypothetical protein -
IG623_RS16960 3698660..3699403 + 744 WP_103808717.1 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
IG623_RS16965 3699462..3699680 + 219 WP_012773205.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
IG623_RS16970 3699683..3699988 + 306 WP_103808718.1 type II toxin-antitoxin system toxin CcdB Toxin
IG623_RS16975 3700340..3702070 + 1731 WP_103808719.1 hypothetical protein -
IG623_RS16980 3702345..3703541 + 1197 WP_103808720.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11786.68 Da        Isoelectric Point: 4.6873

>T174179 WP_103808718.1 NZ_CP062254:3699683-3699988 [Pectobacterium parmentieri]
MQFIVYEYKRASHYKIFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPLLRIDGEDYRLMTTELSSVPVEVIGEVI
VDLSDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T174179 NZ_CP080566:1953933-1954028 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8201.16 Da        Isoelectric Point: 7.2038

>AT174179 WP_012773205.1 NZ_CP062254:3699462-3699680 [Pectobacterium parmentieri]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Download         Length: 219 bp

>AT174179 NZ_CP080566:c1954113-1954056 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E0SK21

References